ArticleJournal of research in health sciences2025
Comparative Analysis of Gender-Specific Patterns of Traditional Coronary Artery Disease Risk Factors and QRISK3 Scores in First-Degree Relatives of Coronary Artery Disease Patients.
Article in Journal of research in health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCoronary artery disease (CAD) is a leading cause of death globally, with genetic and lifestyle factors contributing to its development. The first-degree relatives of CAD patients are at increased risk due to shared genetics and environments. This study aimed to perform a comparative analysis of gender-specific patterns of traditional CAD risk factors and QRISK3 scores in the first-degree relatives of CAD patients.
methodsThis study enrolled 4,485 participants of first-degree relatives of patients who had been admitted to the hospital for CAD. Gender-specific comparisons were conducted in the first-degree relatives of CAD to assess traditional risk factors and QRISK3 scores.
resultsThe mean age of patients was 41.8 years, with males comprising 66% of participants in our study. Males exhibited more traditional risk factors, including higher systolic and diastolic blood pressure, dyslipidaemia, smoking, alcohol, junk food consumption, and oral tobacco use. Females had a higher prevalence of obesity, inadequate sleep, depression, and migraines. Males had a significantly higher 10-year CAD risk according to QRISK3 scores, reflecting an increased healthy heart age of 4.20±1.32 years compared to their chronological age (
conclusionThe prevalence of coronary risk factors was twice as high in the first-degree male relatives of individuals with known CAD compared to females. Distinct gender-based differences were found in risk factors and QRISK3 scores, highlighting the significance of specific approaches in evaluating and managing the risk of CAD within this high-risk group.
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