Evidence map›Paper›PMID 40823959›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Synthesis, Conformal Analysis, and Antibody Binding of Staphylococcus aureus Capsular Polysaccharide Type 5 Oligosaccharides.

Kitt E Østerlid, Sizhe Li, Luca Unione, Linda Del Bino, Charlotte Sorieul, Filippo Carboni, Francesca Berni, Sara Bertuzzi, Bob van Puffelen, Ana Arda and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kitt E Østerlid *Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.
Sizhe Li *Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.
Luca UnioneCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio,Bizkaia, 48160, Spain.
Linda Del BinoGSK Siena, Via Fiorentina, 1, SI, Siena, 53100, Italy.
Charlotte SorieulLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.
Filippo CarboniGSK Siena, Via Fiorentina, 1, SI, Siena, 53100, Italy.
Francesca BerniLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.
Sara BertuzziCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio,Bizkaia, 48160, Spain.
Bob van PuffelenLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.
Ana ArdaCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio,Bizkaia, 48160, Spain.
Herman S OverkleeftLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.
Gijsbert A van der MarelLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.
Maria Rosaria RomanoGSK Siena, Via Fiorentina, 1, SI, Siena, 53100, Italy.
Jesús Jiménez-BarberoCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio,Bizkaia, 48160, Spain.
Roberto AdamoGSK Siena, Via Fiorentina, 1, SI, Siena, 53100, Italy.
Jeroen D C CodéeLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.ORCID 0000-0003-3531-2138

Funding

AEIERC-2023-STG 101117639-Glyco13CellMCINNational Roadmap Large-Scale NMR Facility of the Netherlands 184.035.002Spain for the Severo Ochoa Center of Excellence Accreditation CEX2021-001136-Sthe Marie Skłodowska-Curie 861194 (PAVax)
6 · The paper itself

Abstract

Staphylococcus aureus is one of the most prominent pathogens responsible for life-threatening hospital acquired infections. Most clinical isolates belong to serotype 5 or 8, which express unique capsular polysaccharides (CP), composed of the rare N-acetyl-β-d-mannosaminuronic acid (β-d-ManNAcA), N-acetyl-α-l-fucosamine (α-l-FucNAc) and N-acetyl-β-d-fucosamine (β-d-FucNAc) that can be used for the development of conjugate vaccines. Different acetylation patterns of CP5 create microheterogeneous polymers, carrying partial zwitterionic character, which may be important for immunological activity. We here report on the assembly of a set of conjugation-ready CP5 oligosaccharides, ranging in length from trisaccharides to nonasaccharides. The developed protecting group strategy has allowed the incorporation of N-acetyl, -NH

Indexed as

Antibodies, BacterialOligosaccharidesPolysaccharides, BacterialStaphylococcus aureusBacterial CapsulesCarbohydrate ConformationAntibodies, Bacterialcapsular polysaccharide, type 5, Staphylococcus aureusOligosaccharidesPolysaccharides, BacterialConformational analysisOligosaccharidesStereoselectivitySynthetic vaccines

Identifiers

PMID40823959
PMCPMC12455396

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.