Evidence map›Paper›PMID 40824115›Full record

ReviewNatural product reports2025

Natural products influence bacteriophage infectivity.

Zhiyu Zang, Joseph P Gerdt

Abstract readReview
In one paragraph

Review in Natural product reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zhiyu ZangDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA. zzang@iu.edu.ORCID 0000-0002-4879-7077
Joseph P GerdtDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA. zzang@iu.edu.ORCID 0000-0002-0375-4110

Funding

Elucidation of the first interspecies chemical signaling mechanisms in Capsaspora owczarzaki--the predator of a human pathogen and a model for the evolution of animal multicellularityR35GM138376 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Joseph P. Gerdt · 2020 to 2026
$3.0M
NIGMS NIH HHS R35 GM138376
6 · The paper itself

Abstract

Covering: 1942-2025Bacteriophages (phages) are obligate viruses that infect bacteria. The antibacterial effects of both phages and natural products shape microbial ecosystems and have yielded competing antibiotic strategies. Phages have also intersected many times with natural products research throughout the past century. To discover antiviral leads, natural products were screened for anti-phage activity. To discover new anti-cancer drugs, natural products were screened for the ability to trigger lysis by the λ prophage-indicating DNA damage. Now, the antibiotic resistance crisis motivates the study of natural products that can synergize with phages to improve antibacterial therapies. Beyond applications, these parallel natural "chemical" and "biological" antibacterial factors combine to shape microbial communities across our planet. Here, we provide a comprehensive overview of natural products that modulate phage activities. We discuss their mechanisms of action, and we present opportunities for future research.

Indexed as

BacteriophagesBiological ProductsAnti-Bacterial AgentsBacteriaAnti-Bacterial AgentsBiological Products

Identifiers

PMID40824115
PMCPMC12360287

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.