Evidence map›Paper›PMID 40824359›Full record

ArticleResearch on child and adolescent psychopathology2025

Intergenerational Transmission of Cannabis Use: Testing Genetic Risk and the Mitigating Influences of Parent Positive Behavior Support in Early Childhood.

Savannah G Ostner, Sierra Clifford, Rick A Cruz, Jenn-Yun Tein, Erika Westling, Daniel S Shaw, Jazmin L Brown-Iannuzzi, Melvin N Wilson, Kathryn Lemery-Chalfant

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Research on child and adolescent psychopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Savannah G OstnerDepartment of Psychology, Arizona State University, Tempe, AZ, USA. sostner@asu.edu.ORCID 0000-0003-3499-7112
Sierra CliffordDepartment of Psychology, Arizona State University, Tempe, AZ, USA.
Rick A CruzDepartment of Psychology, Arizona State University, Tempe, AZ, USA.
Jenn-Yun TeinDepartment of Psychology, Arizona State University, Tempe, AZ, USA.
Erika WestlingOregon Research Institute, Springfield, OR, USA.
Daniel S ShawDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Jazmin L Brown-IannuzziDepartment of Psychology, University of Virginia, Charlottesville, VA, USA.
Melvin N WilsonDepartment of Psychology, University of Virginia, Charlottesville, VA, USA.
Kathryn Lemery-ChalfantDepartment of Psychology, Arizona State University, Tempe, AZ, USA.

Funding

Preventing Substance Use in the Context of Poverty: Risk and Protection from Early Childhood to Early AdulthoodR01DA036832 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHAW, DANIEL S, WESTLING, ERIKA · 2014 to 2020
$10.2M
Research training in substance use prevention: Closing the research-practice gapT32DA039772 · NIDA · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Cady Berkel, Nancy A. Gonzales · 2015 to 2026
$4.2M
Parental Involvement, Extra-Familial Contexts and Prevention of Drug Use Risk.R01DA023245 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHAW, DANIEL S · 2007 to 2011
$4.0M
Understanding and Preventing Childhood Drug Use RiskR01DA022773 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHAW, DANIEL S · 2008 to 2012
$3.4M
Preventing Adult Mental Health Problems from Early Childhood in the Contexts of Genetic Susceptibility, Poverty, Racism, and the COVID-19 PandemicR01MH131670 · NIMH · OREGON RESEARCH INSTITUTE · PI Jazmin Brown-Iannuzzi, Kathryn Lemery-Chalfant · 2023 to 2026
$3.3M
Impact of HCV Therapy on CNS OutcomesR01DA039775 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BHARTI, AJAY R · 2015 to 2019
$3.0M
Parent-Child Interaction Dynamics Mediate Genetic and Prevention Effects on the Development of Adolescent Substance Use DisordersR01DA053740 · NIDA · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LEMERY-CHALFANT, KATHRYN, TEIN, JENN-YUN · 2022 to 2025
$1.9M
NIDA NIH HHS DA022773NIDA NIH HHS DA023245NIDA NIH HHS DA036832NIDA NIH HHS DA053740NIDA NIH HHS R01 DA022773NIDA NIH HHS R01 DA023245NIDA NIH HHS R01 DA036832NIDA NIH HHS R01 DA039775NIDA NIH HHS R01 DA053740NIDA NIH HHS T32 DA0039775NIDA NIH HHS T32 DA039772NIMH NIH HHS MH131670NIMH NIH HHS R01 MH131670
6 · The paper itself

Abstract

As the prevalence of Cannabis Use Disorder (CUD) in late adolescence increases, understanding the etiology of CUD is paramount. Consistent with resilience frameworks, the current study examined whether parent cannabis use and genetic risk predicted offspring cannabis use and CUD symptoms in late adolescence. Parental positive behavior support in early childhood was considered as a possible buffer of intergenerational transmission and genetic risk for CUD. The sample consisted of 731 18-year-olds (M = 18.74, SD = 0.50; 50.2% female, 49.8% male; 50% White, 28% Black, 13% Hispanic, 9% Indigenous, Native Hawaiian, or Asian) from the Early Steps Multisite Study. Parent cannabis use was measured at offspring ages 2, 3, 4, 5, 7.5, 8.5, and 9.5, and observational positive behavior support was measured at offspring ages 2, 3, 4, and 5. A polygenic risk score for CUD (CUD PRS) was formed using the PRS-CSx Bayesian technique for genetically diverse samples. CUD symptoms were measured with the SCID-IV interview. Using negative binomial logistic regressions with maximum likelihood, parent cannabis use significantly predicted whether offspring used cannabis, while offspring CUD PRS did not. Further, parental positive behavior support significantly buffered the effect of parent cannabis use on the number of offspring CUD symptoms. Findings suggest that positive parenting in childhood may provide resilience for the intergenerational transmission of cannabis use.

Indexed as

Genetic Predisposition to DiseaseMarijuana AbuseMarijuana UseParent-Child RelationsParentingParentsAdolescentChildChild, PreschoolFemaleHumansMaleRisk FactorsBehavioral geneticsEarly interventionParentingPolygenic riskResilienceSubstance use

Identifiers

PMID40824359
PMCPMC12492698

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.