Evidence map›Paper›PMID 40824414›Full record

ArticleDiscover oncology2025

An oxidative stress related gene signature predicts prognosis in cholangiocarcinoma.

Han Fan, Peng Qiu, Yun Lu, Zhengdong Deng, Li Tian

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Han FanCadre Ward Two, General Hospital of Central Theater Command, Wuhan, 430030, Hubei, China.
Peng QiuDepartment of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Yun LuDepartment of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Zhengdong DengDepartment of Pediatric surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Li TianDepartment of Pediatric surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. tianli0080@tjh.tjmu.edu.cn.

Funding

Natural Science Foundation of China 82103455Youth Fund of Tongji Hospital Foundation 2021A02
6 · The paper itself

Abstract

backgroundCholangiocarcinoma (CCA) is a malignancy with a poor prognosis and limited effective prognostic markers or therapeutic strategies. This study aims to construct and validate a prognostic risk model based on oxidative stress-related genes (OSRGs) to stratify patient risk and guide individualized treatment for CCA.

methodsUsing data from 66 tumors and 36 control samples obtained from the TCGA and GEO databases, we identified 3,632 differentially expressed genes (DEGs). Intersection with oxidative stress-related genes revealed 122 OSRGs, from which 10 key prognostic genes were selected through univariate Cox and LASSO regression analyses. Model performance was assessed with Kaplan-Meier survival, ROC curve, PCA, and t-SNE analyses. Tumor microenvironment (TME) features, immune cell infiltration, and chemosensitivity to cisplatin and 5-fluorouracil were also evaluated.

resultsThe 10-gene model, including genes like RORA and GRIN2A, effectively distinguished between high- and low-risk groups, with high RORA and GRIN2A expression correlating with improved survival. High-risk groups displayed increased immune and ESTIMATE scores, with significant differences in immune cell infiltration. Chemosensitivity analysis indicated differential responses to various chemotherapeutics in high-risk patients.

conclusionThis OSRG-based model demonstrates strong prognostic potential, stratifying CCA patients by risk and survival outcomes. The model provides insights into personalized treatment strategies, potentially advancing therapeutic interventions for CCA.

Indexed as

BioinformaticsCholangiocarcinomaDrug sensitivityImmune infiltrationOxidative stress-related genesPrognostic risk model

Identifiers

PMID40824414
PMCPMC12361017

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.