Evidence map›Paper›PMID 40824557›Full record

Trial reportIrish journal of medical science2025

Impact of royal jelly consumption on oxidative stress, anti-oxidant markers and physical activities of patients with multiple sclerosis: a randomized double-blind placebo-controlled study.

Zahra Eslamifar, Farzaneh Manucheri, Saeed Ghanbari, Mohammadreza Zandi, Susan Sabbagh

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Irish journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zahra EslamifarDepartment of Medical Laboratory Sciences, School of Paramedical Sciences, Dezful University of Medical Sciences, Dezful, Iran.
Farzaneh ManucheriStudent Research Committee, Dezful University of Medical Sciences, Dezful, Iran.
Saeed GhanbariDepartment of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
Mohammadreza ZandiDepartment of Neurology, Ganjavian Hospital, Dezful University of Medical Sciences, Dezful, Iran.
Susan SabbaghDepartment of Anatomical Science, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran. sabagh.s@dums.ac.ir.ORCID http://orcid.org/0000-0001-9662-4173

Funding

Dezful University of Medical Sciences Project. No 98079
6 · The paper itself

Abstract

backgroundThe study investigates the effects of royal jelly (RJ) on patients with relapsing-remitting multiple sclerosis (RRMS), focusing on its potential to reduce oxidative stress, improve antioxidant levels, and enhance quality of life.

methodsA total of 61 RRMS patients were randomly assigned to either a RJ group or a placebo group, receiving a daily dose of 500 mg for 45 days. Key outcomes measured included expanded disability status scale (EDSS) scores, levels of malondialdehyde (MDA), and activities of antioxidants such as catalase (CAT) and superoxide dismutase (SOD), along with assessments of fatigue and quality of life.

resultsResults indicated that the RJ group experienced a significant reduction in EDSS scores (P < 0.001) and MDA levels (P < 0.0001). The activity of SOD and CAT after consumption of RJ had increased significantly (P < 0.0001, P < 0.001), respectively. Additionally, improvements were noted in some parameters of fatigue and quality of life measures.

conclusionThe findings suggest that RJ may help decrease oxidative stress and improve motor function and anti-oxidant capacity in MS patients, potentially slowing disease progression.

trial registrationThis study was registered on the Iranian Registry of Clinical Trials (Registration No. IRCT20220116053732N1) on 2022.05.08.

Indexed as

AntioxidantsExerciseFatty AcidsMultiple Sclerosis, Relapsing-RemittingOxidative StressAdultBiomarkersCatalaseDouble-Blind MethodFatigueFemaleHumansMaleMalondialdehydeMiddle AgedQuality of LifeAntioxidantsBiomarkersCatalaseFatty AcidsMalondialdehydeRoyal JellySuperoxide DismutaseEDSSFatigueMultiple sclerosisOxidative stressQuality of lifeRoyal jelly

Identifiers

PMID40824557

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.