ArticlePsychopharmacology2026
Glutamate delta-1 receptors regulate a tonic excitatory conductance in the mouse bed nucleus of the stria terminalis and influence neuronal function.
Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Inhibition of delta-1 glutamate receptor current by extracellular protons.bioRxiv : the preprint server for biology · 2026Article
- GluD1 at the synaptic crossroads: from domain structure to circuit dysfunction.Acta pharmacologica Sinica · 2026Review
- Glutamate Delta 1 Receptor in Synapses, Circuits, and Disease.The European journal of neuroscience · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
rationaleThe plasticity of ionotropic receptors (mainly AMPARs and NMDARs) within the glutamatergic system has long been investigated as a mechanism for physiological and pathological adaptive learning. The tetrameric delta glutamate receptors (δGluRs, GluD1 and GluD2) are also classified as ionotropic glutamate receptors, however they are insensitive to glutamate. These proteins, especially GluD1, have been implicated in multiple psychiatric conditions and play a functional role in synapses assembly and stability, but recent evidence suggests that they also may supply a tonic excitatory conductance, are sensitive to poly-amine blockade, and regulate synaptic plasticity. GluD1 expression has been noted in the dorsolateral bed nucleus of the stria terminalis (dlBNST), but its function in this region remains unknown.
objectivesWe aimed to functionally characterize δGluRs in the dlBNST and investigate their modulation of both synaptic transmission and cell excitability.
methodsWe used whole-cell patch clamp electrophysiology in male C57BL/6J, GluD1 knockout, and wildtype littermate mice to investigate GluD1 function in the BNST.
resultsOur results suggest that GluD1 carries a tonic conductance, modulates excitatory synapses, and regulates cell excitability in the dlBNST.
conclusionsThese results imply that GluD1 functions to regulate the flow of information through the BNST and modulation of GluD1 funciton could likely contribute to affective behavior governed by the BNST.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.