Evidence map›Paper›PMID 40824760›Full record

ArticleMicrobiology (Reading, England)2025

Genome-wide mapping of cAMP receptor protein binding in enteroaggregative

Munirah M Alhammadi, Joanne Hothersall, Georgina S Lloyd, Sophie V Titman, Thomas Guest, Douglas F Browning, David C Grainger, Stephen J W Busby, James R J Haycocks

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology (Reading, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Munirah M AlhammadiInstitute of Microbiology and Infection, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Joanne HothersallInstitute of Microbiology and Infection, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Georgina S LloydInstitute of Microbiology and Infection, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Sophie V TitmanInstitute of Microbiology and Infection, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Thomas GuestInstitute of Microbiology and Infection, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Douglas F BrowningInstitute of Microbiology and Infection, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
David C GraingerInstitute of Microbiology and Infection, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Stephen J W BusbyInstitute of Microbiology and Infection, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
James R J HaycocksInstitute of Microbiology and Infection, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Bacterial pathogens employ a diverse array of virulence factors to colonize and subsequently elicit disease in their host. These factors are often subject to extensive regulation at the transcriptional level to ensure that their expression is timely. Although many pathogens use bespoke transcription factors that primarily target virulence genes, global transcription factors also sometimes play a role in controlling these genes. Enteroaggregative

Indexed as

Cyclic AMP Receptor ProteinEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialVirulence FactorsBinding SitesGenome, BacterialProtein BindingVirulenceCyclic AMP Receptor ProteinEscherichia coli ProteinsVirulence Factorsbacterial gene regulationcAMP receptor protein (CRP)enteroaggregative Escherichia coli (EAEC)transcriptionvirulence

Identifiers

PMID40824760
PMCPMC12360894

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.