Evidence map›Paper›PMID 40825567›Full record

ArticleJournal of extracellular vesicles2025

Sublytic Activity of a Pore-Forming Protein From Commensal Bacteria Causes Epigenetic Modulation of Tumour-Affiliated Protein Expression.

Eric Toh, Palwasha Baryalai, Aftab Nadeem, Kyaw Min Aung, Si Lhyam Myint, Nikola Zlatkov, Hadis Alidadi, Shaochun Zhu, André Mateus, Deepak Bushan Raina and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of extracellular vesicles, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eric TohDepartment of Molecular Biology, Umeå University, Umeå, Sweden.
Palwasha BaryalaiDepartment of Molecular Biology, Umeå University, Umeå, Sweden.
Aftab NadeemDepartment of Molecular Biology, Umeå University, Umeå, Sweden.
Kyaw Min AungDepartment of Molecular Biology, Umeå University, Umeå, Sweden.
Si Lhyam MyintDepartment of Molecular Biology, Umeå University, Umeå, Sweden.
Nikola ZlatkovDepartment of Molecular Biology, Umeå University, Umeå, Sweden.
Hadis AlidadiDepartment of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden.
Shaochun ZhuUmeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
André MateusThe Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå, Sweden.
Deepak Bushan RainaDepartment of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden.
Madeleine RamstedtUmeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
Bernt Eric UhlinDepartment of Molecular Biology, Umeå University, Umeå, Sweden.
Sun Nyunt WaiDepartment of Molecular Biology, Umeå University, Umeå, Sweden.ORCID https://orcid.org/0000-0003-4793-4671

Funding

Cancerfonden 2017-419Cancerfonden 2020-711Insamlingsstiftelsen Medical Faculty Umeå University 2021-2023Kempestiftelserna SMK-1961Strategic Research Grant, Umeå University 2019-2021Vetenskapsrådet 2018-02914Vetenskapsrådet 2019-01720
6 · The paper itself

Abstract

Cytolysin A (ClyA) is a pore-forming protein from a strongly silenced gene in non-pathogenic Escherichia coli, including typical commensal isolates in the intestinal microbiome of healthy mammalian hosts. Upon overproduction, ClyA-expressing bacteria display a cytolytic phenotype. However, it remains unclear whether sublytic amounts of native ClyA play a role in commensal E. coli-host interactions in vivo. Here, we show that sublytic amounts of ClyA are released via outer membrane vesicles (OMVs) and affect host cells in a remarkable manner. OMVs isolated from ClyA

Indexed as

Colonic NeoplasmsEpigenesis, GeneticEscherichia coliEscherichia coli ProteinsExtracellular VesiclesHemolysin ProteinsCell Line, TumorEnhancer of Zeste Homolog 2 ProteinGastrointestinal MicrobiomeHistonesHumansMicroRNAsReceptors, CXCR4Signal TransductionSTAT3 Transcription FactorTumor Suppressor Protein p53CXCR4 protein, humanEnhancer of Zeste Homolog 2 ProteinEscherichia coli ProteinsEZH2 protein, humanHemolysin ProteinsHistonesMicroRNAsReceptors, CXCR4STAT3 protein, humanSTAT3 Transcription FactorTumor Suppressor Protein p53cancer cell epigeneticsnon‐pathogenic Escherichia coliouter membrane vesiclespore‐forming protein cytolysin A

Identifiers

PMID40825567
PMCPMC12360854

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.