Observational studyThe British journal of ophthalmology2025
Advanced imaging of corneal neovascularisation with a novel swept-source AS-OCTA system.
Observational study in The British journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Circumferential multi-contrast mapping of the aqueous outflow pathway in human eyes facilitated by circular-scan optical coherence tomography angiography.Biomedical optics express · 2026Article
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Authors and funding
9 authors.
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Abstract
aimsTo explore the clinical application of a novel swept-source anterior segment optical coherence tomography angiography (AS-OCTA) system for imaging corneal neovascularisation (CoNV), assessing limbal vasculature and detecting short-term vascular changes following pharmacologic vasoconstriction.
methodsThis cross-sectional observational study included 20 eyes: 10 with clinically diagnosed CoNV of various aetiologies and 10 healthy controls. Each eye underwent AS-OCTA imaging using the BMizar 400kHz Full-Range Swept-Source OCT system at baseline and after administration of 10% phenylephrine (PE). FlowArea (mm
resultsCoNV eyes exhibited significantly higher total and deep corneal FlowArea compared with controls (p=0.0002 and p=0.0005, respectively). Post PE, a significant reduction in FlowArea was observed in the total and deep corneal layers of CoNV eyes (p=0.006 and p=0.009, respectively), and in the limbal region of both groups, with significant reductions observed in CoNV and controls (p=0.006 and p=0.003, respectively).
conclusionsThis AS-OCTA platform enabled high-resolution, depth-resolved visualization of CoNV and revealed vascular changes following topical vasoconstriction. The extended field of view allowed simultaneous assessment of corneal, limbal and episcleral vasculature within a single scan session, supporting its potential role in both diagnostic evaluation and longitudinal monitoring of anterior segment diseases.
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