Evidence map›Paper›PMID 40825663›Full record

ArticleeNeuro2025

Gut Microbiota and White Matter Integrity: A Two-Sample Mendelian Randomization Analysis.

Lan Zhang, Xiao-Wei Pang, Lu-Yang Zhang, Li-Fang Zhu, Wan-Ning Li, Yun-Hui Chu, Luo-Qi Zhou, Dai-Shi Tian, Chuan Qin, Lian Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lan ZhangDepartment of Neurology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
Xiao-Wei PangDepartment of Neurology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
Lu-Yang ZhangDepartment of Neurology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
Li-Fang ZhuDepartment of Neurology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
Wan-Ning LiDepartment of Neurology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
Yun-Hui ChuDepartment of Neurology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
Luo-Qi ZhouDepartment of Neurology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
Dai-Shi TianDepartment of Neurology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China.
Chuan QinDepartment of Neurology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China chenlian318@163.com chuanqin@tjh.tjmu.edu.cn.
Lian ChenDepartment of Neurology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic infectious Diseases, Huazhong University of Science and Technology, Wuhan 430030, China chenlian318@163.com chuanqin@tjh.tjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The causal relationship between gut microbiota (GM) and white matter injury and communication remains unclear. We aimed to scrutinize the plausible causal impact of GM on white matter hyperintensities (WMHs), white matter microstructure, white matter connectivity, and multiple neurological diseases via Mendelian randomization study. We identified four WMH-related bacterial taxa, including class

Indexed as

Gastrointestinal MicrobiomeWhite MatterFemaleHumansMaleMendelian Randomization Analysisgut microbiota; Mendelian randomizationwhite matter connectivitywhite matter hyperintensitieswhite matter microstructure

Identifiers

PMID40825663
PMCPMC12418065

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.