ArticleNature plants2025
Vacuolar sorting receptors coordinate lytic vacuolar and autophagic transport for plant effector-triggered immunity.
Article in Nature plants, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Volatiles released by undamaged plants mediate the adaptive growth strategies in neighbors.Journal of experimental botany · 2026Article
- The BTB/POZ-MATH Protein ZmBPM1 Interacts With Autophagy-related Protein ZmATG6 and Modulates the NLR Protein Rp1-D21-Mediated Defense Response in Maize.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ESCRT: A Cellular Nexus of Plant Immunity and Pathogen Counter-Strategies.Molecular plant pathology · 2026Review
- Multi-Omics Analysis Identifies SlLhcb13 as a Key Regulator of Tomato Resistance toPlants (Basel, Switzerland) · 2026Article
- Entanglement of plant immunity and endomembrane trafficking revealed by plant-powdery mildew fungal interactions.The New phytologist · 2026Review
- Subcellular calcium dynamics and organelle perturbations in resistosome-mediated cell death.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural and Functional Characterization of EXPO-Derived Extracellular Vesicles in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Plant-derived extracellular vesicles for drug delivery: current and future.Regenerative biomaterials · 2026Review
- Tandem Kinase WTK1 Triggers Waves of Transcriptional Reprogramming Underlying Wheat Resistance to Stripe Rust.Physiologia plantarumArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vacuolar sorting receptors (VSRs) are involved in sorting soluble vacuolar proteins during normal plant growth and development, but their role in plant stress responses remains largely unexplored. Here we report that a subgroup of the Arabidopsis thaliana VSR genes are transcriptionally induced during infection with avirulent Pseudomonas syringae strains, leading to higher VSR protein accumulation. We demonstrate that the pathogen-responsive VSR1, VSR5, VSR6 and VSR7 genes function redundantly in sorting vacuolar death-related enzymes induced during bacterial infection. Moreover, VSRs are required for fusion of the tonoplast with the plasma membrane and the subsequent release of vacuolar contents into the apoplast, where bacterial pathogens reside. Indeed, dysfunction of this subgroup of VSRs blocks hypersensitive cell death and leads to stronger disease symptoms and higher bacterial loads, revealing their essential role in defence against avirulent bacterial infection. Intriguingly, their disruption also leads to defects in autophagy, impairing autophagosome-mediated degradation of bacterial effector proteins. Collectively, our results show that VSR1, VSR5, VSR6 and VSR7 are key regulators of plant effector-triggered immunity (ETI) by orchestrating receptor-mediated vacuolar sorting of immunity-related proteins, tonoplast to plasma membrane fusion, and autophagic degradation of effector proteins.
Indexed as
Identifiers
40825852What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.