ArticleDiabetology & metabolic syndrome2025
Switching to insulin degludec/aspart penfill reusable cartridges in patients with type 2 diabetes mellitus: real-life outcomes.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsThis study aimed to evaluate the clinical outcomes of switching from disposable insulin delivery pens to reusable insulin pens with a penfill cartridge system for the co-formulation of insulin degludec and insulin aspart (IDegAsp) in patients with type 2 diabetes (T2D) in Türkiye. We assessed the impact on glycemic control to evaluate the sustainability of this transition.
methodsA total of 226 adults with T2D who were initiating or switching to IDegAsp reusable cartridge insulin pens at a tertiary center in Türkiye were followed for 6 months. Data were retrospectively extracted from the medical records at baseline (prior to switching) and at follow-up visits after 3 and 6 months of IDegAsp Penfill reusable cartridges.
resultsInitiating the IDegAsp reusable cartridge insulin pen in patients who previously used basal-bolus, basal, or premixed insulin therapies with disposable insulin pens was associated with a significant reduction in mean glycated hemoglobin (HbA1c) [mean change -1.0% (95% confidence interval (CI) - 2.2 to - 0.20; p < 0.001)], [- 1.4% (95% CI - 2.3 to - 0.4; p < 0.001)], and [- 0.9% (CI - 1.7 to - 0.1; p < 0.001)]. Switching from IDegAsp disposable insulin pens to the reusable system demonstrated noninferior outcomes [- 0.08% (CI - 0.2 to 0.1; p = 0.629)]. The mean total daily insulin dose and body weight were also significantly lower in patients who were switched from basal-bolus insulin, basal insulin or premixed insulin therapies (p < 0.001 and p < 0.001, respectively).
conclusionInitiating or switching to the IDegAsp reusable pen with the insulin cartridge system in a real-world population of people with T2D in Türkiye was associated with improved or maintained glycemic control.
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