ReviewDiabetology & metabolic syndrome2025
Impact of phytosterol supplementation on metabolic syndrome factors: a systematic review of randomized controlled trials.
Review in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Anticancer Molecular Mechanisms of Phytosterols: An Updated Review on Clinical Trials.Food science & nutrition · 2026Review
- Beneficial Effects ofJournal of obesity · 2026Article
- The association between dietary protein intake and metabolic syndrome: a GRADE-assessed systematic review and meta-analysis of observational studies.Diabetology & metabolic syndrome · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhytosterols (PSs), plant-like organic structures with close similarity to cholesterol, might be useful therapeutically for hypertension, central obesity, dyslipidemia and hyperglycemia, which are components of metabolic syndrome (MetS). This systematic review aimed to evaluate the effects of phytosterol supplementation on MetS components in randomized clinical trials (RCTs).
methodsA systematic search of RCTs published in PubMed/Medline, Web of Science, Embase, Cochrane Library, and Google Scholar up to October 18, 2023. was conducted according to the 2020 Preferred Reporting Items of the Guidelines for Systematic Reviews (PRISMA) statement. The research was updated by January 3, 2025. A total of 14 RCTS of PS intervention on MetS factor were included in a preliminary screening of the retrieved literature by Endnote 21. We assessed the quality of all included randomized controlled trials using the Cochrane Collaboration's Risk of Bias tool.
resultsPS supplementation resulted in a modest improvement in MetS factors. In particular, fasting blood glucose decreased by about 2%, systolic blood pressure decreased by 3-5%, and triglyceride levels dropped by 19-24%. Waist circumference and HDL cholesterol changes were slight, negligible in most cases.
conclusionPS supplementation appears to improve blood pressure, triglyceride levels, and other features of MetS. These findings differ from study to study, and treatment periods were frequently shorter. To fully comprehend the long-term advantages, further well-designed research is required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.