Evidence map›Paper›PMID 40826199›Full record

SynthesisBreast cancer (Tokyo, Japan)2025

Effect of exercise interventions on cognitive function in breast cancer patients and survivors: a systematic review with meta-analysis.

Chen-Sin Hung, Yi-Ting Cheng, Ruei-Hong Li, Charles H Hillman, Neha P Gothe, Feng-Tzu Chen, Hsing-Jung Yeh, Fei-Fei Ren, Yu-Kai Chang

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Breast cancer (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chen-Sin HungDepartment of Physical Education and Sport Sciences, National Taiwan Normal University, Taipei, Taiwan.
Yi-Ting ChengDepartment of Physical Education and Sport Sciences, National Taiwan Normal University, Taipei, Taiwan.
Ruei-Hong LiDepartment of Physical Education and Sport Sciences, National Taiwan Normal University, Taipei, Taiwan.
Charles H HillmanDepartment of Psychology, Northeastern University, Boston, MA, USA.
Neha P GotheDepartment of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, Boston, MA, USA.
Feng-Tzu ChenDepartment of Kinesiology, National Tsing Hua University, Hsinchu, Taiwan.
Hsing-Jung YehDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
Fei-Fei RenDepartment of Physical Education, Beijing Language and Culture University, Beijing, China.
Yu-Kai ChangDepartment of Physical Education and Sport Sciences, National Taiwan Normal University, Taipei, Taiwan. yukaichangnew@gmail.com.

Funding

Ministry of Education as well as "Social Emotional EducationMinistry of Education Development Center" of the Featured Areas Research Center Program within the framework of the HESP of the MOE in TaiwanMinistry of Education National Taiwan Normal University (NTNU) within the framework of the Higher Education Sprout Project (HESP) by the Ministry of Education (MOE) in TaiwanNational Science and Technology Council 113-2410-H-038-032-National Science and Technology Council MOST 110-2410-H-003-142-MY3National Science and Technology Council NSTC 113-2410-H-003-114-MY3
6 · The paper itself

Abstract

backgroundExercise has been shown to facilitate cognitive function; however, data on changes in cognitive function in response to exercise interventions among breast cancer patients and survivors, who frequently experience cognitive impairment, have not been comprehensively synthesized. Therefore, this study aims to examine the impact of exercise interventions on cognitive function among breast cancer patients and survivors.

methodsElectronic databases including PubMed, Scopus, and Web of Science were searched from inception to December 25, 2024. A three-level meta-analysis was performed in R utilizing the standard mean difference. Moderators including cognitive function domains, sample characteristics (i.e., age and timing of exercise), and exercise regimen (i.e., frequency, intensity, type, session time, and length) were examined for subgroup analysis. The methodological quality and the certainty of evidence were evaluated using criteria of the Physiotherapy Evidence Database (PEDro) scale and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, respectively.

resultsA total of 21 identified studies comprising 114 effect sizes were included in the final analysis. Overall, exercise demonstrated a positive small effect size on cognitive function in breast cancer patients and survivors (g = 0.22; 95% confidence interval [CI] 0.07-0.36; p < .001).

conclusionsExercise demonstrated a facilitative effect on various cognitive functions among breast cancer patients during both treatment and survivorship. The non-significant moderation effects further suggest that diverse exercise regimens offer cognitive benefits. However, limited research highlights the need to identify optimal exercise modalities for cognitive enhancement in this population.

Indexed as

Breast NeoplasmsCancer SurvivorsCognitionCognitive DysfunctionExerciseExercise TherapyFemaleHumansCancerCancer-related cognitive impairmentCognitive functionExecutive functionExercise training

Identifiers

PMID40826199
PMCPMC12552352

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.