Evidence map›Paper›PMID 40826253›Full record

ReviewFolia microbiologica2025

Immunological orchestration and dysregulation in COVID-19 pneumonia: from viral pathogenesis to precision therapeutics in the post-pandemic era.

Yun Qin, Chaofan Li, Xingxing Yuan, Zhuying Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Folia microbiologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Immune cell disorder in viral pneumonia.Journal of translational medicine · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yun QinThe Graduate School, Heilongjiang University of Chinese Medicine, Harbin, China.
Chaofan LiThe Graduate School, Heilongjiang University of Chinese Medicine, Harbin, China.
Xingxing YuanDepartment of Internal Medicine, Heilongjiang Academy of Traditional Chinese Medicine, No.33 Xidazhi Street, Nangang District, Harbin, Heilongjiang, 150006, China. yuanxingxing@hljucm.edu.cn.
Zhuying LiDepartment of Respiratory, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, No. 24 Heping Street, Xiangfang District, Harbin, Heilongjiang, 150040, China. lizhuying2025@126.com.ORCID http://orcid.org/0009-0001-2065-2220

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic revolutionized our understanding and treatment of pneumonia, particularly highlighting its complex immunological aspects. In this review, we synthesized recent research on COVID-19 clinical management, shedding light on the immune-related landscape of pneumonia in the post-pandemic era. We explored key features of SARS-CoV-2, such as transmission dynamics, emerging variants, and infection mechanisms, before delving into the host immune response following viral exposure. Our discussion emphasized the critical role of immune cells, inflammatory cytokines, and cytokine storms in pneumonia development, alongside immune-mediated lung damage and thrombotic complications. Clinically, we summarized evolving diagnostic methods, treatment approaches, and intensive care protocols, all with a focus on the pivotal role of immunology in pneumonia management. Looking forward, we advocated for a comprehensive approach to addressing ongoing pneumonia challenges, including strengthening epidemic surveillance and advancing immunotherapy research to target abnormal immune responses. Additionally, refining vaccine strategies for durable immunity against evolving viral strains was deemed essential. Overall, this review underscored the central role of immunology in shaping pneumonia management post-COVID-19, aiming to enhance our understanding of disease mechanisms and immunological responses in the post-pandemic era.

Indexed as

COVID-19SARS-CoV-2Cytokine Release SyndromeCytokinesHumansPandemicsPrecision MedicineCytokinesClinical managementCOVID-19 pneumoniaImmune evasionImmune hyperactivation

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.