ArticleClinical oral investigations2025
Association of tooth loss with circadian syndrome in US adults: the mediated role of systemic inflammation.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundThe current study was to investigate the associations of missing teeth or lost functional tooth units (FTUs) with circadian syndrome and the mediated effects of systemic inflammation as indicated by serum C-reactive protein (CRP).
methodsDentition examination, high-sensitivity serum CRP, and circadian syndrome data of 11,490 participants aged 18-80 years from US National Health and Nutrition Examination Survey 2015-2020 were analyzed. Generalized linear model and mediation effect model were used.
resultsAfter adjusting confounders, the numbers of missing teeth or lost FTUs and Ln-transformed CRP were positively associated with higher circadian syndrome prevalence (odds ratio and 95% confidence interval: missing teeth: 1.01(1.00, 1.01), P = 0.043; lost FTUs: 1.02(1.01, 1.03), P = 0.001; CRP: 1.23(1.20, 1.26), P < 0.001). Furthermore, positive associations between the numbers of missing teeth or lost FTUs and Ln-transformed CRP but inverse association between implant prosthesis and Ln-transformed CRP were observed after adjustment (β ± standard error: missing teeth: 0.012 ± 0.002; lost FTUs: 0.024 ± 0.005; implant prosthesis: -0.136 ± 0.053). Moreover, significant mediation effects of serum CRP were observed in the associations of missing teeth or lost FTUs with circadian syndrome. The mediated proportions (%) for missing teeth or lost FTUs were 32% and 20% respectively.
conclusionsMissing teeth or lost FTUs were positively associated with serum CRP and circadian syndrome in US adults. Systemic inflammation partly mediated the association of missing teeth or lost FTUs with circadian syndrome. CLINICAL RELEVANCE: Maintaining more natural teeth may be associated with lower circadian syndrome prevalence.
Indexed as
Identifiers
40826290What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.