ArticleFluids and barriers of the CNS2025
Subcortical and white matter alterations in canine ventriculomegaly: an observational volumetric and voxel-based-morphometry study.
Article in Fluids and barriers of the CNS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Case Report: Suspected hereditary spontaneous hydrocephalus in a Beagle pedigree.Frontiers in veterinary science · 2026Article
- Investigating gray matter volumes in idiopathic epileptic Border Collies and Greater Swiss Mountain Dogs using voxel-based morphometry.Frontiers in veterinary science · 2026Article
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7 authors.
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Abstract
objectiveVentriculomegaly and hydrocephalus are frequently found during routine clinical imaging, and hydrocephalus in dogs has been shown to alter brain tissue. Although approaches exist to differentiate canine hydrocephalus from ventriculomegaly, information about brain tissue alterations in dogs with ventriculomegaly is lacking. In this observational study, we focused on ventriculomegaly and examined the cerebral anatomical adaptations that accommodate the increased ventricular volume.
methods95 neuroradiological normal diagnosed dogs of different breeds were divided into the two groups, ventriculomegaly and control, according to morphological criteria and ventricle-brain-indices as determined by ratio of brain and lateral ventricle wide. Brain volumetry and voxel-based-morphometry (VBM) were conducted using automatic procedures employing the Statistical Parametric Mapping software and a canine brain atlas.
resultsSignificant alterations in cingulate cortex, caudate nucleus, thalamus, hippocampus, geniculate body as well as corpus callosum were observed in dogs of the ventriculomegaly group by both volumetry and VBM. Interestingly, ventriculomegaly affected only lateral ventricles, the 3rd ventricle, and the mesencephalic aqueduct but not the 4th ventricle. DISCUSSION: A clear distinction between canine hydrocephalus and ventriculomegaly remains difficult and recent research suggests parallels between both. Advances in automated segmentation methods and voxel-based morphometry applicable to canine magnetic resonance imaging offer the opportunity to comprehensively assess structural abnormalities. In addition, clinical assessments are required to investigate the impact of ventriculomegaly on cognitive function and behavior in further studies.
conclusionWe propose the use of a lower ventricle-brain-index threshold of ≥ 0.5 to include all ventricle-associated tissue alterations with potential clinical manifestation.
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