SynthesisEuropean journal of medical research2025
Choroid plexus volume in multiple sclerosis: a systematic review and meta-analysis of an emerging imaging biomarker.
Synthesis in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Choroid plexus volume in Alzheimer's disease: A systematic review and meta-analysis.Journal of Alzheimer's disease : JAD · 2026Pooled it
- Choroid Plexus MRI Features and Cognitive Outcomes in Multiple Sclerosis: A Scoping Review.Brain sciences · 2026Review
- Glymphatic surrogate, choroid plexus remodeling, and exploratory brain network analysis in the post-acute phase of anti-NMDAR encephalitis: multimodal MRI evidence for cognitive associations and differential white matter mediation.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe choroid plexus (CP), as a structure located in the ventricles of the brain, is a critical site of immune signaling, and many studies have claimed that it may act as a biomarker for multiple sclerosis (MS). This review aimed to assess the CP volume (CPV) in people with MS (PwMS) and its correlation with disability scores and magnetic resonance imaging (MRI) metrics.
methodsA systematic search was conducted across four databases of PubMed/MEDLINE, Embase, Scopus, and Web of Science databases, covering the period from their inception until January 25, 2025. The meta-analysis was performed using a random-effects model to determine the pooled standard mean difference (SMD) of normalized CP (nCPV) between PwMS and healthy controls (HCs), and its correlation with MRI metrics and disability scores.
resultsA total of 27 studies were included, encompassing 1346 PwMS. The nCPV was found to be significantly higher in PwMS as compared to HCs (SMD = 1.12, 95% CI 0.68 to 1.56, p value < 0.01). In addition, nCPV exhibited the strongest correlations with normalized ventricular volume and (r = 0.59, 95%CI 0.5 to 0.68, p < 0.01) and gray matter volume (r = - 0.41, 95% CI - 0.57 to - 0.24, p < 0.01, I
conclusionCPV is observed to be elevated in PwMS and exhibits correlations with disability scores and MRI metrics. Consequently, CPV may be a potential diagnostic and disease activity biomarker for MS. However, the strong correlation with the atrophy surrogate of ventricular volume necessitates further investigation. PROSPERO REGISTRATION ID: CRD42024586066.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.