ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Development of Rapid and Economic In Vitro Assay and Biorelevant Ex Vivo Biofilm Inhibition Wound Model to Test the Antibacterial Efficacy of Wound Dressings.
Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Evaluation of a Commercial Ozonated Olive Oil Product (800 mEq OPathogens (Basel, Switzerland) · 2026Article
- Preclinical Performance Evaluation of an Oxidized Regenerated Cellulose Hemostat: Antibacterial Activity and Wound Healing Outcomes.Medical devices (Auckland, N.Z.) · 2026Article
- Development of Rapid and Economic In Vitro Assay and Biorelevant Ex Vivo Biofilm Inhibition Wound Model to Test the Antibacterial Efficacy of Wound Dressings.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Chronic wounds are a major healthcare problem, consuming resources globally and necessitating innovative wound dressing development. All antimicrobial wound dressings must be tested for safety and antibacterial effectiveness prior to patient use. This study aimed to develop a rapid, economical in vitro assay and biorelevant ex vivo wound biofilm model on porcine skin to test the antibacterial efficacy of antimicrobial wound dressings. The methods were validated using five commercially available wound dressings and experimental electrospun (ES) wound dressing containing chloramphenicol in polycaprolactone and polyethylene oxide fibres (PCL/PEO/CAM). An in vitro assay was used to assess the growth inhibition, killing efficacy, and dressing sterility against multiple bacterial strains and inoculum sizes. Ex vivo models using porcine skin were used to evaluate biofilm inhibition with dressings on top of or inside infected wounds. The in vitro assay allowed rapid initial screening, whilst ex vivo models provided more biorelevant conditions for understanding the efficacy in wound-mimicking environments. The assay and model are suitable for rapid evaluation of antimicrobial efficacy before animal studies and clinical trials. Using various commercially available wound dressings alongside novel dressings for validation ensures that the method is broadly applicable. The antibacterial efficacy of commercial antimicrobial wound dressings and experimental ES PCL/PEO/CAM fibre mat was confirmed. This study highlights the importance of using multiple complementary assays and models to comprehensively assess antimicrobial wound dressing materials.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.