ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Physical activity and blood-based biomarkers of neurodegeneration in community dwelling Australians from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease).
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Review
- Associations of plasma biomarkers of Alzheimer's disease pathology with modifiable risk factors and cognitive and functional outcomes: evidence from cross-sectional prediction and latent path analyses in the Bio-Hermes-001 cohort.Alzheimer's research & therapy · 2026Article
- Health-related factors and their impact on blood-based biomarkers of Alzheimer's disease.Aging brain · 2026Article
- Physical activity and blood-based biomarkers of neurodegeneration in community dwelling Australians from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease).Alzheimer's & dementia (Amsterdam, Netherlands)Article
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7 authors.
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Abstract
Introduction: Physical activity, a key modifiable risk factor for dementia, has been associated with biomarkers of neurodegeneration in the central nervous system, but less is known regarding blood-based biomarkers. Methods: A total of 739 cognitively healthy participants (aged 50-83 years) from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease) completed a battery of online surveys. Self-reported physical activity was assessed based on daily metabolic equivalent, and a blood sample was analyzed for serum neurofilament light chain, serum glial fibrillary acidic protein (GFAP), plasma phosphorylated tau, and genotyped for apolipoprotein E ( Results: Higher self-reported physical activity was significantly associated with lower log-transformed concentrations of GFAP (pg/mL, Discussion: This cross-sectional study provides novel evidence for the association of physical activity with blood-based biomarkers of neurodegeneration, and how HIGHLIGHTS: We looked at a large-scale (
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