Evidence map›Paper›PMID 40827182›Full record

ArticleCureus2025

G-Protein-Coupled Receptor Class C Group 6 Member A (GPRC6A) and Serine Protease Inhibitor, Kazal Type 1 (SPINK1) Genotypes Associated With Refractory Functional Dyspepsia: A Potential Link to Endosonographic Features.

Sakura Higashida, Seiji Futagami, Ken Nakamura, Shuhei Agawa, Mayu Habiro, Rie Kawawa, Takeshi Onda, Tomohide Tanabe, Nobue Ueki, Masanori Atsukawa

Abstract read
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sakura HigashidaDivision of Gastroenterology, Nippon Medical School, Tokyo, JPN.
Seiji FutagamiDivision of Gastroenterology, Nippon Medical School, Tokyo, JPN.
Ken NakamuraDivision of Gastroenterology, Nippon Medical School, Tokyo, JPN.
Shuhei AgawaDivision of Gastroenterology, Nippon Medical School, Tokyo, JPN.
Mayu HabiroDivision of Gastroenterology, Nippon Medical School, Tokyo, JPN.
Rie KawawaDivision of Gastroenterology, Nippon Medical School, Tokyo, JPN.
Takeshi OndaDivision of Gastroenterology, Nippon Medical School, Tokyo, JPN.
Tomohide TanabeDivision of Gastroenterology, Nippon Medical School, Tokyo, JPN.
Nobue UekiDivision of Gastroenterology, Nippon Medical School, Tokyo, JPN.
Masanori AtsukawaDivision of Gastroenterology, Nippon Medical School, Tokyo, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aims to determine the associations between single-nucleotide polymorphisms (SNPs) in

methodsAround 97 patients with FD and 74 R-FD were recruited. Five pancreatic enzymes were measured. DNA was isolated from blood or duodenal tissues. Endoscopic ultrasonography (EUS) was performed using Olympus EUS (GF-UCT 260; Olympus, Tokyo, Japan) under conscious sedation in patients with R-FD. Exocrine or endocrine pancreatic function was estimated.

resultsSignificant differences (p < 0.001) were observed in the ratio of abnormal pancreatic enzyme levels between patients with R-FD and those with FD. However, no significant differences in the distribution of

conclusionSignificant differences (p < 0.001) were observed in the ratio of abnormal pancreatic enzyme levels between patients with R-FD and those with FD.

Indexed as

early chronic pancreatitisendoscopic ultrasonographygprc6apolymorphismrefractory functional dyspepsiaspink1

Identifiers

PMID40827182
PMCPMC12358054

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.