ArticleESC heart failure2025
Epicardial, visceral and subcutaneous adipose tissue in heart failure with preserved ejection fraction.
Article in ESC heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Prognostic value of epicardial and pericardial adipose tissue in patients with chronic heart failure.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026Article
- Review
- Adipose Tissue, Natriuretic Peptides, and HFpEF: Clinical Implications of the Obesity Paradox.Biomedicines · 2026Review
- Response to the letter to the editor: Epicardial, visceral and subcutaneous adipose tissue in heart failure with preserved ejection fraction.ESC heart failure · 2026Article
- Adipokine profile in acute heart failure: associations with natriuretic response and prognosis.ESC heart failure · 2026Observational
- 'Letter to the editor: Epicardial, visceral and subcutaneous adipose tissue in heart failure with preserved ejection fraction'.ESC heart failure · 2025Article
- Reply: Epicardial Fat and Exercise Hemodynamics in Female-Predominant HFpEF.JACC. Advances · 2025Article
- Epicardial, visceral and subcutaneous adipose tissue in heart failure with preserved ejection fraction.ESC heart failure · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
aimsObesity is common in patients with heart failure with preserved ejection fraction (HFpEF), and adipose tissue (AT) plays a key role in its pathophysiology. We examined the distribution and association of visceral AT (VAT), subcutaneous AT (SAT) and epicardial AT (EAT) in HFpEF using multimodality imaging.
methodsHeart failure patients with left ventricular ejection fraction >40% were prospectively enrolled. All patients underwent cardiac magnetic resonance (CMR) imaging and total body computed tomography (CT). EAT was measured on CMR, and VAT, SAT and waist circumference (WC) were measured on CT. Linear regression analysis was used to assess associations between EAT and other AT depots.
resultsIn total, 68 patients were included. Mean age was 73 ± 8 years; 34 (50%) were women. Twenty-six patients (38%) were obese, while 60 (91%) had increased WC and 58 (85%) had increased VAT. Body mass index (BMI) and WC were comparable between men and women, but men had more EAT (217 vs. 180 mL, P < 0.001) and VAT (306 vs. 196 cm
conclusionsThe distribution of various AT depots is markedly different between men and women with HFpEF. Men have more VAT and EAT, but less SAT. The observed variation in AT depots may potentially contribute to gender-related differences in cardiovascular risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.