ArticleThe Journal of head trauma rehabilitation
Traumatic Brain Injury and Accelerated Epigenetic Aging Among Post-9/11 Veterans.
Article in The Journal of head trauma rehabilitation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Epigenetic mechanisms in traumatic brain injury: a focus on astrocytes and therapeutic implications.Journal of neuroinflammation · 2026Review
- Accelerated biological aging and midlife frailty among U.S. military veterans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Observational
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveMilitary service over the last several decades has been associated with an increased risk of injuries, including traumatic brain injury (TBI). Veterans with a history of TBI often experience poor health outcomes and have higher rates of premature mortality. In this study, we examined whether accelerated biological aging could help explain negative health outcomes following TBI. SETTING, PARTICIPANTS, AND
designWe evaluated the association between TBI and rate of epigenetic aging (assessed using DunedinPACE) using data from post-9/11 veterans ( N = 1152) enrolled in the VA Mid-Atlantic (VISN 6) MIRECC Post-Deployment Mental Health cohort study. MAIN MEASURES: TBI was assessed using self-report during a clinical interview categorized into three TBI groups (none, 1, 2 +), epigenetic aging was assessed using DunedinPACE derived from DNA methylation data.
resultsVeterans who reported more lifetime TBI (β = 0.07, 95% CI [0.01, 0.14], P = .029) or deployment-related TBI (β = 0.09, 95% CI [0.01, 0.18], P = .046) had faster epigenetic aging. TBI during and after military service was more strongly associated with accelerated aging than TBI prior to military service, and deployment-related TBI was more strongly associated with accelerated aging for women veterans. Overall, associations were small to moderate in size.
conclusionThese findings show TBI could increase risk for accelerated aging and underscores its potential utility in identifying veterans who may face aging-related health issues. Early identification of TBI-related accelerated aging could inform interventions that mitigate long-term health risks as post-9/11 veterans transition into middle and older age.
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Registered trials
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