Evidence map›Paper›PMID 40828028›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Asymmetric development and function of paired sperm-storage organs in

Dawn S Chen, Kianairy Marrero, Javier Arturo Sanchez-Lopez, Michael Belenky, Jonathon M Thomalla, Norene A Buehner, Ido Apel, Yarin Levi, Yassi Hafezi, Shuran Wang and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dawn S Chen *Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.
Kianairy Marrero *Center for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003.
Javier Arturo Sanchez-Lopez *Department of Entomology, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.ORCID 0000-0003-4684-1238
Michael BelenkyDepartment of Entomology, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.
Jonathon M ThomallaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.
Norene A BuehnerDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.
Ido ApelDepartment of Entomology, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.
Yarin LeviDepartment of Entomology, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.
Yassi HafeziDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.
Shuran WangDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.
Andrew G ClarkDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.ORCID 0000-0001-7159-8511
Yael HeifetzDepartment of Entomology, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.ORCID 0000-0002-6997-7704
Mark L SiegalCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003.ORCID 0000-0001-6930-2988
Mariana F WolfnerDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-2701-9505

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
TAKASHIMA DIVERSITY SUPPLEMENT TO: REGULATION OF GAMETE USE AND NEURAL PATHWAYS IN REPRODUCTIONR01HD059060 · NICHD · CORNELL UNIVERSITY · PI ANDREW G CLARK, Mariana Federica Wolfner · 2009 to 2026
$5.8M
Actions of Seminal Proteins in Mated Drosophila FemalesR37HD038921 · NICHD · CORNELL UNIVERSITY · PI Mariana Federica Wolfner · 2020 to 2026
$2.7M
Genetic and Nongenetic Variation in Complex TraitsR35GM148344 · NIGMS · NEW YORK UNIVERSITY · PI Mark L Siegal · 2023 to 2026
$1.7M
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD059060HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R37HD038921HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM148344Israel Science Foundation (ISF) ISF-2041/17Mann Award, Cornell University 2024NICHD NIH HHS R01 HD059060NICHD NIH HHS R37 HD038921NIGMS NIH HHS R35 GM148344NIH HHS P40 OD018537
6 · The paper itself

Abstract

Paired structures often have similar forms and functions, but the processes underlying their formation can differ. They may originate from a common source or from parallel sources, or arise from distinct precursors that follow separate developmental pathways, ultimately converging on comparable structures and roles. When asymmetries emerge and persist through development, members of the pair can specialize in ways that might increase fitness. Here, we report that the

Indexed as

Drosophila melanogasterSpermatozoaAnimalsCalciumDrosophila ProteinsFemaleGene Expression Regulation, DevelopmentalHomeodomain ProteinsMaleTranscription FactorsWnt1 ProteinCalciumDrosophila ProteinsEn protein, DrosophilaHomeodomain ProteinsTranscription Factorswg protein, DrosophilaWnt1 Proteincalciumcompartmentspaired organsspermathecasperm storage

Identifiers

PMID40828028
PMCPMC12403100

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.