Evidence map›Paper›PMID 40828232›Full record

ReviewTissue engineering and regenerative medicine2025

Three-Dimensional Bioprinting and Infertility-Related Female Reproductive System Diseases: A Review of Current and Future Applications.

Yanyan Liu, Yuanyuan Ma, Lihong Wang, Congmei Liu, Xianghua Huang, Jingkun Zhang

Abstract readReview
In one paragraph

Review in Tissue engineering and regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Exploring endometriosis through 3DMaterials today. Bio · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yanyan LiuDepartment of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Yuanyuan MaDepartment of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Lihong WangDepartment of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Congmei LiuDepartment of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Xianghua HuangDepartment of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Jingkun ZhangDepartment of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, China. zhangjingk110110@hebmu.edu.cn.ORCID http://orcid.org/0009-0000-3845-8867

Funding

Medical Science Research Project of Hebei 20240487S&T Program of Hebei H2021206463
6 · The paper itself

Abstract

backgroundInfertility has a significant impact on women, affecting them both mentally and physically. Some of the current infertility-related diseases include intrauterine adhesions, endometriosis, polycystic ovary syndrome, primary ovarian insufficiency, and cancer. While existing treatments can help slow diseases progression and improve fertility for some patients, overall recovery rates remain low. The use of three-dimensional bioprinting (3D bioprinting) is becoming increasingly popular in clinical settings due to its high precision, customizable materials, and mechanical properties. In the state of infertility, its therapeutic potential is becoming more evident.

methodsIn this paper, we summarized the current treatment status of female infertility-related diseases, including cervical cancer, ovarian cancer, endometrial cancer, polycystic ovary syndrome, intrauterine adhesions, MRKH syndrome and other diseases, used databases such as PubMed, described the research progress and future development direction of 3D bioprinting in these diseases.

results3D bioprinting technology could help repair damaged endometrial and ovarian tissue, and was able to create cell-loaded biological scaffolds to help restore the structure and function of affected organs. Furthermore, the development of organoids is opening new ways for research in regenerative medicine. It is expected that 3D bioprinting will not only be able to create organoid structures for research purposes but will also be utilized in clinical settings to effectively address infertility.

conclusions3D bioprinting is gaining popularity in the clinical field due to its high resolution, adjustable composition, and mechanical qualities. Infertility-related disorders damage women by inflicting a psychological and functional double blow. According to the current research, the application of 3D bioprinting technology to help patients restore fertility function has endless possibilities in the future.

Indexed as

BioprintingGenital Diseases, FemaleInfertility, FemalePrinting, Three-DimensionalFemaleHumans3D bioprintingDiseasesFemale reproductive systemInfertility

Identifiers

PMID40828232
PMCPMC12640408

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.