Evidence map›Paper›PMID 40828473›Full record

ReviewArchives of microbiology2025

The molecular mechanisms of quinolone resistance in Salmonella: a review.

Jing Wang, Zichun Sang, Yifei Zhao, Qiwen Wang, Xiaowen Hu, Ting Ni, Chang Liu, Huobing Liao, Heyu Zhang, Xingyu Xia

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jing WangHenan University of Science and Technology, Luoyang, China. wjnhyhhh@163.com.
Zichun SangHenan University of Science and Technology, Luoyang, China. sangzichun1212@163.com.
Yifei ZhaoHenan University of Science and Technology, Luoyang, China.
Qiwen WangHenan University of Science and Technology, Luoyang, China.
Xiaowen HuHenan University of Science and Technology, Luoyang, China.
Ting NiHenan University of Science and Technology, Luoyang, China.
Chang LiuHenan University of Science and Technology, Luoyang, China.
Huobing LiaoHenan University of Science and Technology, Luoyang, China.
Heyu ZhangHenan University of Science and Technology, Luoyang, China.
Xingyu XiaHenan University of Science and Technology, Luoyang, China.

Funding

Innovation Training Program for College Students in Henan Province S202510464084
6 · The paper itself

Abstract

Salmonella is an important foodborne pathogen, and its quinolone resistance poses a considerable threat to public health. This review comprehensively analyzes various quinolone resistance mechanisms of Salmonella, including mutations in genes encoding drug targets, export of quinolones by efflux pump systems, decrease in Salmonella cell permeability, and the formation of special physiological states. The gyrA and parC are two important genes encoding the drug targets of quinolones, and their genetic mutations result in the drug targets being unable to be recognized by quinolones. Many efflux pumps, such as AcrAB, MdtABC, MdsABC, EmrAB, etc., transport quinolones out of Salmonella cells. A reduction in the expression of some porins decreases quinolone permeability, further aggravating drug resistance. In addition, special physiological states of Salmonella, such as a low metabolic state, biofilms, and quorum sensing, significantly increase quinolone resistance of Salmonella. The development of quinolone resistance in Salmonella is a complex process involving the synergistic effects of multiple mechanisms.

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialQuinolonesSalmonellaBacterial ProteinsHumansAnti-Bacterial AgentsBacterial ProteinsQuinolonesDrug resistanceEfflux pumpsGene mutationsPhysiological statesQuinolonesSalmonella

Identifiers

PMID40828473

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.