Evidence map›Paper›PMID 40828907›Full record

ArticleScience signaling2025

Amylin receptor subunit interactions are modulated by agonists and determine signaling.

Sandra E Gostynska, Jordan A Karim, Bailee E Ford, Peyton H Gordon, Katie M Babin, Asuka Inoue, Nevin A Lambert, Augen A Pioszak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science signaling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The evolving landscape of obesity pharmacotherapy.Nature reviews. Drug discovery · 2026
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sandra E GostynskaDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-3728-3767
Jordan A KarimDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-2001-5176
Bailee E FordDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Peyton H GordonDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0009-0009-5194-9586
Katie M BabinDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-7357-393X
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.ORCID 0000-0003-0805-4049
Nevin A LambertDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA.ORCID 0000-0001-7550-0921
Augen A PioszakDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0003-2637-8928

Funding

RAMP-altered Class B GPCR Hormone RecognitionR01GM104251 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI PIOSZAK, AUGEN A · 2012 to 2024
$4.2M
Conventional and unconventional GPCR-G protein couplingR35GM145284 · NIGMS · AUGUSTA UNIVERSITY · PI Nevin Alan Lambert · 2022 to 2026
$1.8M
NIGMS NIH HHS R01 GM104251NIGMS NIH HHS R35 GM145284
6 · The paper itself

Abstract

Three amylin receptors (AMYRs) mediate the metabolic actions of the peptide hormone amylin and are drug targets for diabetes and obesity. AMY

Indexed as

Amylin Receptor AgonistsReceptors, Islet Amyloid PolypeptideSignal TransductionAnimalsCyclic AMPHEK293 CellsHumansIslet Amyloid PolypeptideProtein BindingProtein MultimerizationProtein SubunitsRatsReceptor Activity-Modifying Protein 1Receptor Activity-Modifying Protein 2Receptor Activity-Modifying Protein 3Receptors, CalcitoninAmylin Receptor AgonistsCyclic AMPIslet Amyloid PolypeptideProtein SubunitsReceptor Activity-Modifying Protein 1Receptor Activity-Modifying Protein 2Receptor Activity-Modifying Protein 3Receptors, CalcitoninReceptors, Islet Amyloid Polypeptide

Identifiers

PMID40828907
PMCPMC12410446

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.