ArticleJournal of the Royal Society, Interface2025
Emergent dynamics of cellular decision making in multi-node mutually repressive regulatory networks.
Article in Journal of the Royal Society, Interface, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Bayesian Decision-Making Shapes Phenotypic Landscapes from Differentiation to Cancer.Entropy (Basel, Switzerland) · 2026Article
- Emergent dynamics of cellular decision making in multi-node mutually repressive regulatory networks.Journal of the Royal Society, Interface · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Stem cell differentiation during development is governed by the dynamics of the underlying gene regulatory networks (GRNs). Mutually inhibiting nodes/collection of nodes encompass the GRNs that govern differentiation to two distinct fates. However, the properties of GRNs that can allow differentiation into n-terminal phenotypes are poorly understood. In this study, we examine toggle-n networks, encompassing mutual inhibitions among multiple transcription factors (TFs), to derive generalized insights regarding the dynamics underlying differentiation into n-terminal phenotypes. We show through numerical and analytical methods that steady-state distributions of these networks involve co-expression of multiple cell state-specific TFs, indicating the presence of multi-potent hybrid phenotypes during multi-lineage differentiation. Furthermore, incorporating a case study of T-helper cell differentiation, we show that cytokine signalling and specific asymmetry of regulatory links can drive further directed differentiation of these hybrid phenotypes into particular cell states within our mathematical framework.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.