ReviewAmerican journal of perinatology2026
Clinical Impact of the PDA and Its Management on Outcomes of Preterm Infants with NEC: A Review.
Review in American journal of perinatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Understanding the Impact of Patent Ductus Arteriosus and Treatment Strategies on Acute Kidney Injury in Preterm Infants.American journal of perinatology · 2026Review
- High-throughput analysis of multimodal monitoring data: the role of machine learning in early warning systems for high-risk neonates.BMJ paediatrics open · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal emergencies in preterm infants. The pathogenesis of NEC is not clearly established and multifactorial. Preterm infants are at increased risk for NEC because of intestinal immaturity, resulting in potential mucosal injury. Circulatory instability has been proposed as a key indicator for ischemic insult to the gut, leading to NEC. With the increased incidence of patent ductus arteriosus (PDA) in preterm infants less than 32 weeks and in babies with birth weight less than 1,500 g, several studies propose an association of NEC with a hemodynamically significant PDA. This review provides an extensive literature search for NEC and PDA in the PUBMED database. In this study, we will review the pathogenesis of NEC and the relationship between PDA and NEC. We will also explore the different treatment options for PDA and their relationship to the incidence of NEC. While earlier diagnosis and aggressive treatment of NEC have improved the outcomes, the disease still accounts for 10% of deaths in infants in the neonatal intensive care unit. With resuscitation of increasingly earlier gestational age infants, the incidence of both hemodynamically significant PDA and NEC is rising, denoting the importance of understanding the inter-relationship of these two pathophysiological processes. · The relationship between PDA and NEC is studied.. · The pathophysiology of NEC is described.. · Propose future directions for the use of advanced technologies to identify at-risk preterm infants..
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.