Evidence map›Paper›PMID 40830352›Full record

ArticleScientific reports2025

HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition.

Guochun Liu, Binyi Zhao, Qinglong Chen, Xiang Li, Xuejiao Zhu, Maowei Duan, Mengdie Zhang, Zhuohan Liu, Xuan Wen, Jia Guo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Guochun LiuChongqing Medical University, Chongqing, China.
Binyi ZhaoFirst Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany.
Qinglong ChenChongqing Medical University, Chongqing, China.
Xiang LiChongqing Medical University, Chongqing, China.
Xuejiao ZhuChongqing Medical University, Chongqing, China.
Maowei DuanChongqing Medical University, Chongqing, China.
Mengdie ZhangChongqing Medical University, Chongqing, China.
Zhuohan LiuChongqing Medical University, Chongqing, China.
Xuan WenDivision of Sports Science and Physical Education, Tsinghua University, Beijing, China.
Jia GuoDivision of Sports Science and Physical Education, Tsinghua University, Beijing, China.
Man ZhengDivision of Sports Science and Physical Education, Tsinghua University, Beijing, China.
Ruiyu WangEmergency Medicine Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. wangruiyu@med.uestc.edu.cn.
Minghao LuoChongqing Medical University, Chongqing, China. luominghao001@hospital.cqmu.edu.cn.

Funding

Natural Science Foundation of Chongqing, China (No. CSTB2022NSCQ-MSX0111 and No. CSTB2024NSCQ-MSX1212)
6 · The paper itself

Abstract

Atherosclerosis (AS), driven by vascular endothelial dysfunction and poses a global health threat. This study compared the therapeutic effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on vascular endothelial function in early-stage AS mice, specifically investigating PCSK9 modulation and the TRX/TXNIP/NLRP3/GSDMD-N pathway. ApoE

Indexed as

AtherosclerosisEndothelium, VascularHigh-Intensity Interval TrainingPCSK9 InhibitorsPhysical Conditioning, AnimalProprotein Convertase 9AnimalsDiet, High-FatDisease Models, AnimalMaleMiceMice, Inbred C57BLOxidative StressPCSK9 InhibitorsPcsk9 protein, mouseProprotein Convertase 9AtherosclerosisEndothelial dysfunctionExercisePyroptosis

Identifiers

PMID40830352
PMCPMC12365230

What Socratic holds

Texttitle and abstract
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.