ArticleBMC infectious diseases2025
Predictive value of combined detection of blood Urea nitrogen and Neutrophil-to-lymphocyte ratio for identifying severe pneumonia complicated with sepsis in neonates.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between neutrophil to lymphocyte ratio and the mortality of patients with sepsis: an update systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Clinical significance of LINC01093 in children with severe pneumonia and its regulation of miR‑326/MAPK1 axis.BMC pediatrics · 2026Article
- Comparison of C-reactive protein/albumin ratio and neutrophil/lymphocyte ratio with conventional biomarkers for predicting septic shock in pediatric sepsis.BMC pediatrics · 2026Article
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9 authors.
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Abstract
backgroundNewborns with severe pneumonia are at a high risk of developing sepsis, and early identification of this risk can improve the prognosis for the affected children. The purpose of this study was to evaluate the predictive value of combining blood urea nitrogen (BUN) and neutrophil-to-lymphocyte ratio (NLR) in diagnosing neonatal severe pneumonia complicated with sepsis (NSPCS).
methodsWe retrospectively included 194 newborns hospitalized from January 2018 to December 2021. Of these, 51 newborns with severe pneumonia developed sepsis. Clinical and laboratory data were collected from electronic medical records. The newborns were divided into severe pneumonia and sepsis groups. Multivariate logistic regression analysis was performed to determine whether BUN and NLR were independent predictors of NSPCS. The predictive value of combining BUN and NLR was assessed using receiver operating characteristic (ROC) curve analysis.
resultsNewborns with severe pneumonia complicated by sepsis had elevated levels of BUN (P < 0.001) and NLR (P = 0.003). Correlation analysis indicated a positive correlation between NSPCS and levels of BUN (r = 0.341, P < 0.001) and NLR (r = 0.213, p = 0.003). Multiple logistic regression analysis revealed that BUN and NLR were independent risk factors for NSPCS. ROC curve analysis revealed that combining BUN and NLR had better efficacy in identifying NSPCS (AUC = 0.757, 95% CI: 0.681–0.834, P < 0.001), with significantly better discriminatory ability than either BUN (AUC = 0.724, 95% CI: 0.643–0.804, P < 0.001) or NLR (AUC = 0.640, 95% CI: 0.545–0.735, P = 0.003) alone.
conclusionThe combined detection of BUN and NLR was a valuable biomarker for identifying NSPCS. WHAT IS KNOWN: Newborns with severe pneumonia are at a high risk of developing sepsis, and early identification of this risk can improve the prognosis for the affected children. The clinical symptoms of neonatal sepsis are nonspecific, and the diagnostic criteria are unclear. Identifying effective biomarkers for early detection of neonatal severe pneumonia complicated with sepsis (NSPCS) could significantly improve clinical outcomes. WHAT IS NEW: This study determined the risk factors for NSPCS. The combined measurement of BUN and NLR levels may be a valuable biomarker for identifying NSPCS, providing clinicians with a reference for accurate diagnosis and treatment.
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