Evidence mapPaperPMID 40830670Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2026

Mini-review and situation report on the role and usefulness of nuclear medicine imaging for malaria.

Janie Duvenhage, Jan Rijn Zeevaart, Mike Machaba Sathekge, Thomas Ebenhan

Abstract readReview
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Janie DuvenhageNuclear Medicine Research Infrastructure NPC, Pretoria, South Africa.ORCID 0000-0002-5770-7213
Jan Rijn ZeevaartNuclear Medicine Research Infrastructure NPC, Pretoria, South Africa.ORCID 0000-0003-0794-3012
Mike Machaba SathekgeNuclear Medicine Research Infrastructure NPC, Pretoria, South Africa.ORCID 0000-0002-2806-0625
Thomas EbenhanNuclear Medicine Research Infrastructure NPC, Pretoria, South Africa. Thomas.ebenhan@up.ac.za.ORCID 0000-0002-2038-7324

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria remains one of the deadliest parasitic diseases globally. Delay or failure in treatment can lead to the development of severe malaria. Severe malaria, an understudied multisystem disease, affects the host's organs and can lead to several syndromes and serious complications, some effecting life-long neurological and cognitive sequela. There is a lack in knowledge regarding the molecular mechanisms underlying severe malaria pathogenesis, and research has mostly relied on post-mortem studies and animal models, both of which lack translatability to human malaria. This review presents the clinical nuclear imaging techniques used in malaria. Although the presented radiopharmaceuticals have added value to understand some aspects of severe malaria, there has been in stagnation in development of more malaria-specific radiopharmaceuticals. This manuscript highlights the current limitations for implementing improved radiopharmaceuticals and provides valuable insights on how these challenges can be overcome.

Indexed as

MalariaNuclear MedicineAnimalsHumansRadiopharmaceuticalsRadiopharmaceuticalsCerebral malariaNuclear imagingPlasmodiumPositron-emission tomographySevere malaria

Identifiers

PMID40830670
PMCPMC12830474

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.