ArticleDiabetology & metabolic syndrome2025
Association between atherogenic index of plasma and type 2 diabetes in women with a history of gestational diabetes mellitus: a cross-sectional study.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between atherogenic index of plasma and various metabolic conditions: an umbrella review on meta-analyses.BMC cardiovascular disorders · 2025Pooled it
- Atherogenic index of plasma predicts gestational diabetes mellitus and correlates with disease severity and adverse pregnancy outcomes.Journal of endocrinological investigation · 2026Article
- Lipidomic signatures in gestational diabetes mellitus and postpartum type 2 diabetes mellitus: a narrative review of etiologic and predictive implications.EBioMedicine · 2026Review
- Atherogenic index of plasma in early pregnancy: associations with gestational diabetes mellitus and preeclampsia and its mediating role.Lipids in health and disease · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Atherogenic Index of Plasma (AIP) is a novel lipid parameter calculated as the logarithmic ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) levels. Initially proposed as a marker for predicting cardiovascular disease risk and atherosclerosis, AIP has more recently been found to be closely associated with insulin resistance, metabolic syndrome, and the development of type 2 diabetes(T2DM). However, its role in women with a history of GDM, a unique high-risk population, remains unclear. This study aims to investigate the relationship between the AIP and type 2 diabetes (T2DM) prevalence in women with a history of GDM.
methodsA cross-sectional analysis was conducted using data from 4,690 parous women from the 2007-2018 National Health and Nutrition Examination Survey (NHANES), with participants stratified by GDM history. Multivariate logistic regression models were applied to evaluate the association between the AIP and T2DM among women with a history of GDM. Subgroup analyses and interaction tests were performed within the GDM group to explore effect modification. Restricted cubic spline (RCS) models were used to assess the linearity of the association between the AIP and T2DM prevalence. Mediation analysis was also conducted to examine whether the AIP score mediated the relationship between GDM history and T2DM.
resultsAmong women with a history of GDM, higher AIP values were significantly associated with increased T2DM prevalence. A dose-response relationship was observed across AIP quartiles, with women in the highest quartile showing a markedly elevated risk (adjusted OR = 5.01, 95% CI: 1.89, 13.25, p < 0.01). RCS analysis revealed a linear association between AIP and T2DM in this population. Mediation analysis further revealed that the AIP partially mediated the association between GDM and T2DM, accounting for 8.0% of the total effect (95% CI: 5.1-12.5%).
conclusionAIP is associated with T2DM prevalence in women with a history of GDM. These findings indicate that the AIP may serve as a potential early indicator for identifying individuals at elevated risk of progressing from GDM to T2DM.
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