Evidence map›Paper›PMID 40830909›Full record

ArticleJournal of biophotonics2025

Comparative Analysis of Reflectance Confocal Microscopy and Multiphoton Microscopy in Basal Cell Carcinoma Diagnosis.

Wenwen Zhong, Lingyang Long, Ying Feng, Xiahui Han, Jianxin Chen

Abstract readComparative Study
In one paragraph

Article in Journal of biophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenwen ZhongDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.ORCID 0009-0001-3585-4650
Lingyang LongKey Laboratory of Optoelectronic Science and Technology for Medicine of the Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, China.
Ying FengKey Laboratory of Optoelectronic Science and Technology for Medicine of the Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, China.
Xiahui HanKey Laboratory of Optoelectronic Science and Technology for Medicine of the Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, China.
Jianxin ChenKey Laboratory of Optoelectronic Science and Technology for Medicine of the Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, China.ORCID 0000-0001-8519-4462

Funding

Natural Science Foundation of Fujian Province 2022J01216
6 · The paper itself

Abstract

backgroundBasal cell carcinoma (BCC), the most common skin malignancy, requires early diagnosis for optimal outcomes. This study evaluates the complementary roles of reflectance confocal microscopy (RCM) and multiphoton microscopy (MPM) in BCC characterization.

methodsForty-seven histopathologically confirmed BCC lesions were analyzed. Preoperative dermoscopy and in vivo RCM imaging were performed; post-excision specimens underwent MPM imaging and H&E correlation.

resultsRCM demonstrated superior visualization of tumor nests and vascular patterns, while MPM provided quantitative collagen analysis, revealing significant architectural differences between high- and low-risk subtypes (p < 0.01).

conclusionThe combined approach enhances diagnostic accuracy, with RCM enabling rapid assessment and MPM facilitating risk stratification through collagen metrics.

Indexed as

Basal Cell CarcinomaMicroscopy, Fluorescence, MultiphotonSkin NeoplasmsAgedFemaleHumansMaleMicroscopy, ConfocalMiddle Agedbasal cell carcinoma (BCC)collagen fiber morphologymultiphoton microscopy (MPM)reflectance confocal microscopy (RCM)second‐harmonic generation (SHG)

Identifiers

PMID40830909
PMCPMC12702637

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.