Evidence map›Paper›PMID 40830985›Full record

ReviewStem cell research & therapy2025

Multi-function of adipose-derived stem cells on gut disorder: from bench to bedside.

Jiatong Zhao, Shuzi Xin, Xiaohui Liu, Weikai Shi, Boya Wang, Hongli Wang, Yi Wang, Rongxuan Hua, Yize Li, Lei Gao and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Doxorubicin-Induced Cytotoxicity in Adipose-Derived Stem Cells Is Associated With Altered SAPK/JNK Signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiatong Zhao *Department of Clinical Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Shuzi Xin *Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Xiaohui Liu *Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Weikai ShiDepartment of Clinical Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Boya WangKey laboratory of Carcinogenesis and Translational Research Ministry of Education, Beijing, China.
Hongli WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Yi WangDepartment of Clinical Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Rongxuan HuaDepartment of Clinical Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Yize LiDepartment of Clinical Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Lei GaoDepartment of Biomedical Informatics, School of Biomedical Engineering, Capital Medical University, Beijing, 100069, China.
Xin LuExperimental Center for Morphological Research Platform, Capital Medical University, Beijing, 100069, China.
Jingdong XuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. xujingdong@ccmu.edu.cn.

Funding

National Natural Science Foundation of China 82174056National Natural Science Foundation of China 82474161Natural Science Foundation of Beijing Municipality 7242211
6 · The paper itself

Abstract

Adipose-derived stem cells (ADSCs) are a specific type of mesenchymal stem cells (MSCs) obtained easily from adipose tissue (AT). Compared with MSCs, ADSCs are easier to obtain, have fewer ethical issues, and have a higher proliferative capacity, which makes them a promising type of stem cell in regenerative medicine. ADSCs possess impressive capabilities in cell regeneration as well as differentiation, making them promising candidates for injury repair, tissue regeneration and alleviation of inflamed tissues. At present, most clinical studies on ADSCs focus on the treatment of wounds, multiple sclerosis, soft tissue trauma, aging, diabetes, Parkinson’s disease, bone and cartilage regeneration, stroke, and spinal cord injury, while its clinical applications in the gastrointestinal tract are relatively few. Therefore, this review summarizes the findings of preclinical experiments, clinical trials, and areas that may require further development of ADSCs in the treatment of digestive disorders, including inflammatory bowel disease (IBD), colorectal cancer (CRC), colorectal fibrosis, hepatocellular carcinoma, hepatic fibrosis, gastric cancer (GC), gastrostomy closure and radiation-induced proctitis. The review is concluded by discussing the goals for improvement and future directions for ADSCs before large-scale clinical application.

Indexed as

Adipose TissueGastrointestinal DiseasesMesenchymal Stem CellsMesenchymal Stem Cell TransplantationAnimalsCell DifferentiationHumansInflammatory Bowel DiseasesRegenerative MedicineStem CellsAdipose-derived stem cellsAnti-inflammationFibrosisImmunoregulatory effectsInflammatory bowel diseaseMesenchymal stem cells

Identifiers

PMID40830985
PMCPMC12366020

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.