Evidence map›Paper›PMID 40831062›Full record

ArticleBiophysical journal2025

Prediction of α

Siva Dasetty, Robert E Coffman, Tamara C Bidone, Andrew L Ferguson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Siva DasettyPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois. Electronic address: sivadasetty@uchicago.edu.
Robert E CoffmanScientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah.
Tamara C BidoneDepartment of Biomedical Engineering, University of Utah, Salt Lake City, Utah; Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah.
Andrew L FergusonPritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois; Department of Chemistry, University of Chicago, Chicago, Illinois.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The adhesion protein integrin is a transmembrane heterodimer that plays a pivotal role in cellular processes such as cell signaling and cell migration. To execute its function, integrin undergoes extensive conformational changes from a bent-closed to an extended-open state. Resolving the structures across these changes remains a challenge with both experimental and computational methods, but it is crucial for understanding the activation mechanism of integrin. We address this challenge for the platelet integrin α

Indexed as

Platelet Glycoprotein GPIIb-IIIa ComplexHumansModels, MolecularProtein ConformationThermodynamicsPlatelet Glycoprotein GPIIb-IIIa Complex

Identifiers

PMID40831062
PMCPMC12709499

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.