Evidence map›Paper›PMID 40831465›Full record

ArticleEClinicalMedicine2025

Impact of metabolic dysfunction on treatment responses to nucleos(t)ide analogues in chronic hepatitis B: a retrospective multi-center REAL-B cohort study.

Rui Huang, Dae Won Jun, Hidenori Toyoda, Yao-Chun Hsu, Huy Trinh, Akito Nozaki, Toru Ishikawa, Tsunamasa Watanabe, Haruki Uojima, Daniel Q Huang and 44 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

54 authors.

Rui HuangDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA.
Dae Won JunDepartment of Internal Medicine, Hanyang University, College of Medicine, Seoul, South Korea.
Hidenori ToyodaDepartment of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan.
Yao-Chun HsuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan.
Huy TrinhSan Jose Gastroenterology, San Jose, CA, USA.
Akito NozakiGastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
Toru IshikawaDepartment of Gastroenterology, Saiseikai Niigata Hospital, Niigata, Japan.
Tsunamasa WatanabeDivision of Gastroenterology, St. Marianna University School of Medicine, Kawasaki, Japan.
Haruki UojimaDepartment of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Daniel Q HuangDivision of Gastroenterology and Hepatology, National University Hospital, Singapore.
Takashi HondaDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yasuhito TanakaDepartment of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Philip VutienDivision of Gastroenterology and Hepatology, University of Washington, Seattle, WA, USA.
Sebastián MarcianoJefe de Hepatología - Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Hiroshi AbeDivision of Gastroenterology and Hepatology, Shinmatsudo Central General Hospital, Chiba, Japan.
Masaru EnomotoDepartment of Hepatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Masanori AtsukawaDivision of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan.
Hirokazu TakahashiLiver Center, Saga University Hospital, Saga, Japan.
Kunihiko TsujiCenter for Gastroenterology, Teine Keijinkai Hospital, Sapporo, Japan.
Ei ItobayashiDepartment of Gastroenterology, Asahi General Hospital, Chiba, Japan.
Koichi TakaguchiDepartment of Hepatology, Kagawa Prefectural Central Hospital, Kagawa, Japan.
Pei-Chien TsaiHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chia-Yen DaiHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Jee-Fu HuangHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chung-Feng HuangHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ming-Lun YehHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Eileen YoonDepartment of Internal Medicine, Hanyang University, College of Medicine, Seoul, South Korea.
Sung Eun KimDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang-si, South Korea.
Sang Bong AhnDepartment of Internal Medicine, Nowon Eulji Medical Center, Eulji University College of Medicine, Seoul, South Korea.
Gi-Ae KimDepartment of Internal Medicine, Kyung Hee University School of Medicine, Seoul, South Korea.
Jang Han JungDepartment of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong-si, South Korea.
Soung Won JeongDepartment of Internal Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University Seoul Hospital, Seoul, South Korea.
Hyunwoo OhDivision of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Cheng-Hao TsengDivision of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Cancer Hospital/I-Shou University, Kaohsiung, Taiwan.
Masatoshi IshigamiDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Angela ChauDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA.
Tiffany HsiaoDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA.
Mayumi MaedaDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA.
Satoshi YasudaDepartment of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan.
Makoto ChumaGastroenterological Center, JCHO Yokohama Hodogaya Central Hospital, Yokohama, Japan.
Takanori ItoDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Keigo KawashimaDepartment of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Joanne Kimiko LiuDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA.
Adrian GadanoJefe de Hepatología - Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Ritsuzo KozukaDepartment of Hepatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Norio ItokawaDivision of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan.
Kaori InoueLiver Center, Saga University Hospital, Saga, Japan.
Tomonori SenohDepartment of Hepatology, Kagawa Prefectural Central Hospital, Kagawa, Japan.
Jie LiDepartment of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Wan-Long ChuangHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ramsey CheungDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA.
Chao WuDepartment of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Ming-Lung YuHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Mindie H NguyenDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Metabolic dysfunction is associated with liver disease but it is unclear if it would impact responses to antiviral treatment in chronic hepatitis B (CHB) patients. Methods: Using data from an international consortium of 4507 treatment-naïve CHB patients who initiated nucleos(t)ide analogues (NAs) between January 2004 and August 2024 from 32 centers and propensity-score matching (PSM) to balance the background of patients with and without metabolic disease (diabetes, obesity, dyslipidemia, or hypertension), we compared their biochemical (BR), virologic (VR), and complete (CR) response. Findings: More than half (54.8%) had at least one metabolic disease. Patients with metabolic disease (vs. no) were older and more likely male. In the PSM cohort of 893 pairs of patients, patients with metabolic disease had significantly lower 5-year cumulative BR (91.3% vs. 95.8%, Interpretation: The presence and number of metabolic diseases were significantly and incrementally associated with lower BR. Metabolic disease should be taken into consideration in the management of CHB patients receiving NAs treatment. Funding: None.

Indexed as

Chronic hepatitis BMetabolic diseasesNucleos(t)ide analoguesTreatment response

Identifiers

PMID40831465
PMCPMC12359161

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.