Evidence map›Paper›PMID 40831706›Full record

ArticleBioactive materials2025

Tannic acid-loaded zinc- and copper-doped mesoporous bioactive glass nanoparticles: Potential antioxidant nanocarriers for wound healing.

Sara Pourshahrestani, Irem Unalan, Ehsan Zeimaran, Zhiyan Xu, Judith A Roether, Andrea Kerpes, Christina Janko, Christoph Alexiou, Aldo R Boccaccini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sara PourshahrestaniInstitute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany.
Irem UnalanInstitute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany.
Ehsan ZeimaranInstitute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany.
Zhiyan XuInstitute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany.
Judith A RoetherInstitute of Polymeric Materials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Martensstrasse 7, 91058 Erlangen, Germany.
Andrea KerpesDepartment of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, University Hospital Erlangen, 91054 Erlangen, Germany.
Christina JankoDepartment of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, University Hospital Erlangen, 91054 Erlangen, Germany.
Christoph AlexiouDepartment of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, University Hospital Erlangen, 91054 Erlangen, Germany.
Aldo R BoccacciniInstitute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyphenols such as tannic acid (TA) with antibacterial and antioxidant activities have recently attracted significant attention for wound healing applications. Mesoporous bioactive glass nanoparticles (MBGNs) have also garnered considerable interest to be employed as nanocarriers of therapeutic biomolecules. This study focuses on the fabrication of TA-loaded MBGNs which were doped with two well-known biologically active elements, copper (Cu) and zinc (Zn). The effect of TA loading on the antioxidant and biological properties of the nanoparticles was investigated in the context of potential wound healing applications. As proven with various techniques, TA was successfully loaded on CuMBGNs and ZnMBGNs. With increasing TA concentration, the phenolic content in the nanoparticles was found to increase and CuMBGNs-TA and ZnMBGNs-TA were found to possess 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. The nanoparticles not only showed biocompatibility towards normal human dermal fibroblast (NHDF) cells, but they were also found to be hemocompatible. In comparison to CuMBGNs-TA leachates resulting in

Indexed as

CopperMesoporous bioactive glass nanoparticlesTannic acidWound healingZinc

Identifiers

PMID40831706
PMCPMC12359053

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.