Evidence map›Paper›PMID 40831710›Full record

ArticleBioactive materials2025

Bioinspired porous core-shell microspheres with spatiotemporal delivery coordinate immunomodulatory-osteogenic coupling via NF-κB/P-STAT6 and Rho/MAPK signaling for enhanced calvarial regeneration.

Jiahe Zheng, Chengrun Li, Qingxia Zhang, Tao Ou, Linlong Li, Pengfei Yu, Shujuan Wei, Guige Hou, Huanhuan Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Bone organoids and mitochondrial reprogramming.Journal of orthopaedic translation · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. [Antibacterial properties, biocompatibility, and clinical selection strategies of root canal filling materials for primary teeth].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiahe ZhengSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, 264003, PR China.
Chengrun LiSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, 264003, PR China.
Qingxia ZhangSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, 264003, PR China.
Tao OuSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, 264003, PR China.
Linlong LiKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, PR China.
Pengfei YuSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, 264003, PR China.
Shujuan WeiR & D Center, Luye Pharma Group Ltd., Yantai, 264003, PR China.
Guige HouSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, 264003, PR China.
Huanhuan YanSchool of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, 264003, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Critical-sized calvarial defects remain a formidable clinical challenge due to dyssynchronous immunomodulation-osteogenesis coupling and unregulated growth factor release. Here, a bioinspired porous core-shell microsphere system (GCI@HPPS) is developed, integrating hydroxyapatite (HA)-loaded shell, surface-immobilized SDF-1α, and IGF-1-encapsulated cores to immunomodulate osteoimmune microenvironment and osteogenesis promotion. The hierarchical architecture achieved spatiotemporally programmed release: HA degradation-dependent mineralization, SDF-1α-mediated BMSC chemotaxis, and sustained IGF-1 delivery, mimicking natural bone repair cascades. Dual covalent/guest-host crosslinking (GelMA/Ac-β-CD) enhanced compressive strength, while polydopamine functionalization of microspheres conferred electroactivity, hydrophilicity, ROS/RNS scavenging (97.29 % ABTS•+ elimination), antibacterial efficacy (>99.8 %) and hemostasis.

Indexed as

Core-shell microsphereCritical-sized bone defectImmunoregulationOsteogenic regenerationSequential release

Identifiers

PMID40831710
PMCPMC12358963

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.