ArticleFrontiers in pediatrics2025
Expression and clinical significance of Klotho protein in serum, umbilical cord blood, and placenta of pregnant women with intrauterine growth restriction.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Editorial: Physiology and pathophysiology of placenta.Frontiers in endocrinology · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Intrauterine growth restriction (IUGR) significantly affects neonatal development, but its pathogenesis is not fully understood. Klotho protein is involved in aging-related diseases, and its role in fetal growth is unclear. This study aims to explore Klotho's role in IUGR. Methods: A case-control study was conducted at Nanning Maternal and Child Health Care Hospital from July 2023 to June 2024. Fifty-two neonates (gestational age ≥34 weeks and <42 weeks) were divided into the appropriate for gestational age (AGA) group ( Results: The IUGR group showed placental morphological changes, including increased syncytial knots and inflammation. Klotho expression in placental tissue was significantly reduced ( Conclusions: Reduced Klotho expression in IUGR cases, along with changes in GH and IGF-1, suggests disruptions in metabolic processes affecting fetal growth and development. These findings suggest a potential involvement of Klotho in placental changes and fetal development, warranting further mechanistic studies.
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