Evidence map›Paper›PMID 40832200›Full record

ArticlebioRxiv : the preprint server for biology2025

A minimal model for the role of Rim4 in regulating meiotic exit in budding yeast.

V Abigail Marquez Davila, Pallavi Gadgil, Anna Zike, Gisela Cairo, Renyu Wang, Sima Setayeshgar, Soni Lacefield

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

V Abigail Marquez DavilaDepartment of Physics, Indiana University Bloomington, Indiana, USA.
Pallavi GadgilDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Anna ZikeDepartment of Biology, Indiana University, Bloomington, Indiana, USA.
Gisela CairoDepartment of Physics, Indiana University Bloomington, Indiana, USA.
Renyu WangDepartment of Physics, Indiana University Bloomington, Indiana, USA.
Sima SetayeshgarDepartment of Physics, Indiana University Bloomington, Indiana, USA.
Soni LacefieldDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0002-2862-5067

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9M
NCI NIH HHS P30 CA023108NIGMS NIH HHS P20 GM113132
6 · The paper itself

Abstract

Meiosis ensures formation of haploid gametes through two rounds of chromosome segregation after one round of DNA replication. How this complex cell cycle process is restricted to two and only two divisions is poorly understood. In budding yeast, RNA-binding protein Rim4 binds various mRNAs to prevent their translation. At the onset of meiosis II, phosphorylation and degradation of Rim4, along with the concomitant release of sequestered mRNA, has an important role in ensuring meiotic exit. Building on previous work, we developed a parsimonious mathematical model of meiotic termination that elucidates the role of Rim4-mRNA release and translation of

Identifiers

PMID40832200
PMCPMC12363912

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.