Evidence map›Paper›PMID 40832298›Full record

ArticlebioRxiv : the preprint server for biology2025

Surgical Removal of Visceral Adipose Tissue has Therapeutic Benefit in Male APP

Samuel A McFadden, Yimin Fang, Kathleen Quinn, Mackenzie R Peck, Jenelle E Chapman, Tiarra Hill, Andrzej Bartke, Erin R Hascup, Kevin N Hascup

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Samuel A McFaddenDale and Deborah Smith Center for Alzheimer's Research and Treatment, Springfield, IL, USA.ORCID 0000-0002-2289-5066
Yimin FangDale and Deborah Smith Center for Alzheimer's Research and Treatment, Springfield, IL, USA.ORCID 0000-0001-9270-5857
Kathleen QuinnDale and Deborah Smith Center for Alzheimer's Research and Treatment, Springfield, IL, USA.
Mackenzie R PeckDale and Deborah Smith Center for Alzheimer's Research and Treatment, Springfield, IL, USA.ORCID 0000-0002-2611-1150
Jenelle E ChapmanDale and Deborah Smith Center for Alzheimer's Research and Treatment, Springfield, IL, USA.
Tiarra HillDale and Deborah Smith Center for Alzheimer's Research and Treatment, Springfield, IL, USA.ORCID 0009-0000-7995-842X
Andrzej BartkeInternal Medicine, Springfield, IL, USA.ORCID 0000-0002-2569-557X
Erin R HascupDale and Deborah Smith Center for Alzheimer's Research and Treatment, Springfield, IL, USA.
Kevin N HascupDale and Deborah Smith Center for Alzheimer's Research and Treatment, Springfield, IL, USA.ORCID 0000-0001-6604-1874

Funding

NIA NIH HHS R01 AG057767NIA NIH HHS R01 AG061937
6 · The paper itself

Abstract

Purpose: Visceral white adipose tissue (vWAT) accumulation causes systemic inflammation, insulin resistance, metabolic syndrome, and senescent cell accumulation that are risk factors for Alzheimer's disease (AD). Visceral fat removal (VFR) improves metabolism and reduces proinflammatory cytokines. We hypothesized that VFR removal in AD mice would improve metabolism and cognition. Methods: Male and female APP Results: Male and female APP Conclusions: Sex-specific differences in glucose and lipid metabolism and lipid accumulation underlie the divergent responses to VFR in APP

Indexed as

Alzheimer’s diseasecell senescenceglucose and lipid metabolisminflammationlipectomyvisfatinwhite adipose tissue

Identifiers

PMID40832298
PMCPMC12363911

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.