Evidence map›Paper›PMID 40832338›Full record

ArticlebioRxiv : the preprint server for biology2025

Cis-regulatory evolution of

Kenta Tomihara, Ana Pinharanda, Young Mi Kwon, Andrew M Taverner, Laura Kors, Matthew L Aardema, Julia C Holder, Lin Poyraz, Patrick F Reilly, Takashi Kiuchi and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kenta TomiharaDepartment of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, University of Tokyo; Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan.ORCID 0000-0001-7067-7146
Ana PinharandaDepartment of Biological Sciences, Columbia University; 1212 Amsterdam Avenue, New York, NY, 10027, USA.ORCID 0000-0002-4696-9218
Young Mi KwonDepartment of Biological Sciences, Columbia University; 1212 Amsterdam Avenue, New York, NY, 10027, USA.
Andrew M TavernerLewis-Sigler Institute for Integrative Genomics, Princeton University; Princeton, NJ, 08544, USA.
Laura KorsDepartment of Biology, Barnard College, Columbia University; New York, NY 10027, USA.
Matthew L AardemaDepartment of Biology, Montclair State University; Montclair, NJ, 07043, USA.
Julia C HolderDepartment of Biological Sciences, Columbia University; 1212 Amsterdam Avenue, New York, NY, 10027, USA.
Lin PoyrazDepartment of Biological Sciences, Columbia University; 1212 Amsterdam Avenue, New York, NY, 10027, USA.
Patrick F ReillyLewis-Sigler Institute for Integrative Genomics, Princeton University; Princeton, NJ, 08544, USA.
Takashi KiuchiDepartment of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, University of Tokyo; Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan.
Peter AndolfattoDepartment of Biological Sciences, Columbia University; 1212 Amsterdam Avenue, New York, NY, 10027, USA.ORCID 0000-0003-3393-4574

Funding

Parallel evolution at Na,K-ATPase: a model system for understanding constraints on the evolution of novel protein functions.R01GM115523 · NIGMS · PRINCETON UNIVERSITY · PI ANDOLFATTO, PETER · 2015 to 2024
$2.8M
Dissecting the molecular basis and assembly of a complex morphological traitR01GM114093 · NIGMS · PRINCETON UNIVERSITY · PI ANDOLFATTO, PETER, REBEIZ, MARK J · 2015 to 2018
$1.8M
The evolution of a co-opted gene-regulatory network underlying a rapidly evolving morphological traitR01GM112758 · NIGMS · PRINCETON UNIVERSITY · PI ANDOLFATTO, PETER, REBEIZ, MARK J · 2016 to 2019
$1.7M
NIGMS NIH HHS R01 GM112758NIGMS NIH HHS R01 GM114093NIGMS NIH HHS R01 GM115523
6 · The paper itself

Abstract

Closely related species often exhibit distinct morphologies that can contribute to species-specific adaptations and reproductive isolation. One example are Lepidopteran caterpillar appendages, such as the "caudal horn" of Bombycoidea moths, which have evolved substantial morphological diversity among species in this group. Using interspecific crosses, we identify the genetic basis of the caudal horn size difference between

Identifiers

PMID40832338
PMCPMC12363878

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.