ArticlemedRxiv : the preprint server for health sciences2025
Effects of Minimally Processed Red Meat Within a Plant-Forward Diet on Biomarkers of Physical and Cognitive Aging: A Randomized Controlled Crossover Feeding Trial.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Lean-pork Within a Plant-based Dietary Pattern for Improving Iron Reserve, Muscle-fitness, and Markers of Health Span in Older Adults: A Multi-disciplinary Randomized Controlled Feeding Study
Effect of Minimally Processed Animal Protein on Biomarkers for Cognitive Decline
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5 authors.
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Abstract
Background: Popular dietary patterns for cardiovascular and cognitive health such as the Mediterranean and MIND diets emphasize plant-based foods while limiting red meat intake. However, most research combines processed and unprocessed forms, limiting conclusions about unprocessed red meat. Objective: To evaluate the effects of incorporating minimally processed lean red meat into a nutrient-dense, plant-forward, healthy dietary pattern on markers of aging-associated health decline. Methods: This 18-week all-food-provided randomized controlled crossover feeding PRODMED2 trial tested an omnivorous red meat diet with 162g/d minimally processed pork (MPP) against a macronutrient- and energy-matched no-meat control diet with minimally processed lentils (MPL). Serum biomarkers relevant to metabolic-related cognitive and physical health were explored in 36 adults aged ≥65 years. Primary and secondary endpoints included five cardiovascular-related markers, 12 nutrition- and neurotransmitter-related measures, two metrics of body composition, and two muscular fitness outcomes. Data was analyzed using robust mixed effects models adjusted for covariates. Results: Intervention diets were well tolerated, with high adherence. Improvements in cognitive related metabolic biomarkers were observed across both arms. Fasting insulin declined more after MPP ( Conclusion: These findings challenge the perception that red meat is broadly unsuitable for older adults. Including familiar foods like red meat, particularly in minimally processed form and within a healthy overall dietary pattern, may provide age-associated health benefits and improve adherence to plant-forward diets. These results have important implications for healthspan of older U.S. populations where red meat remains popular. Clinical Trial Registry: Registered at www.clinicaltrials.gov as NCT05581953 and NCT06261775 .
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Registered trials
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