Evidence map›Paper›PMID 40832383›Full record

ArticlemedRxiv : the preprint server for health sciences2025

The

Evan B Hale, Barbara Vona, Richard J Goodyear, Richard T Osgood, Sami S Amr, Karen Mojica, Ricardo Vera-Monroy, Katherine Callahan, Kerry L Gudlewski, Rolen Quadros and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Evan B HaleMass Eye and Ear, Eaton Peabody Laboratories, Boston, MA, 02114, USA.ORCID 0000-0002-2781-0412
Barbara VonaInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany.ORCID 0000-0002-6719-3447
Richard J GoodyearSchool of Life Sciences, University of Sussex, Falmer, Brighton, UK.
Richard T OsgoodMass Eye and Ear, Eaton Peabody Laboratories, Boston, MA, 02114, USA.ORCID 0000-0002-0347-9614
Sami S AmrDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Karen MojicaDepartment of Otolaryngology, Vivian Pellas Hospital, Managua, Nicaragua.
Ricardo Vera-MonroySection of Otolaryngology-Head and Neck Surgery, Department of Surgery, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, NH, 03766, USA.
Katherine CallahanSection of Otolaryngology-Head and Neck Surgery, Department of Surgery, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, NH, 03766, USA.
Kerry L GudlewskiSection of Otolaryngology-Head and Neck Surgery, Department of Surgery, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, NH, 03766, USA.
Rolen QuadrosDepartment of Genetics, Cell Biology, and Anatomy, Nebraska Medical Center, Omaha, NE, 68198, USA.
Masato OhtsukaDivision of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University, Kanagawa, Japan.
JoAnn McGeeDevelopmental Auditory Physiology Laboratory, Boys Town National Research Hospital, Omaha, NE, 68131, USA.
Edward J WalshDevelopmental Auditory Physiology Laboratory, Boys Town National Research Hospital, Omaha, NE, 68131, USA.
Cynthia C MortonDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Channabasavaiah GurumurthyDepartment of Genetics, Cell Biology, and Anatomy, Nebraska Medical Center, Omaha, NE, 68198, USA.ORCID 0000-0002-8022-4033
James E SaundersSection of Otolaryngology-Head and Neck Surgery, Department of Surgery, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, NH, 03766, USA.
Guy P RichardsonSchool of Life Sciences, University of Sussex, Falmer, Brighton, UK.
Artur A IndzhykulianMass Eye and Ear, Eaton Peabody Laboratories, Boston, MA, 02114, USA.ORCID 0000-0002-2076-6818

Funding

TRAINING FOR SPEECH AND HEARING SCIENCEST32DC000038 · NIDCD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Gwenaelle S Geleoc · 1992 to 2026
$21.8M
Molecular Basis of Hair Cell Stereocilia Bundle MorphologyR01DC017166 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI INDZHYKULIAN, ARTUR · 2018 to 2022
$3.5M
Development of Gene Therapy for Hereditary Deafness using Rational Protein EngineeringR01DC020190 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI DAVID P COREY, Artur Indzhykulian · 2022 to 2026
$3.3M
Calcium Regulation in Cochlear CellsR01DC021795 · NIDCD · CASE WESTERN RESERVE UNIVERSITY · PI Artur Indzhykulian, Ruben Stepanyan · 2025 to 2026
$1.3M
Effects of the TECTB-C225Y Variant in the Inner EarF31DC021855 · NIDCD · HARVARD MEDICAL SCHOOL · PI HALE, EVAN BROWN · 2024 to 2025
$75k
NIDCD NIH HHS F31 DC021855NIDCD NIH HHS R01 DC017166NIDCD NIH HHS R01 DC020190NIDCD NIH HHS R01 DC021795NIDCD NIH HHS T32 DC000038
6 · The paper itself

Abstract

Identifying new genes responsible for non-syndromic hearing loss remains a critical goal, as many individuals with hereditary deafness still lack a molecular diagnosis despite comprehensive genetic testing. The tectorial membrane (TM) is a specialized, collagen-rich, acellular matrix of the inner ear, essential for stimulating mechanosensitive hair cell bundles during sound transduction, and its structural integrity is critical for frequency tuning and auditory sensitivity. Although mutations in genes encoding a number of non-collagenous proteins found in the TM (TECTA, CEACAM16, OTOG, OTOGL) have been identified as deafness genes, definitive evidence implicating β-tectorin (TECTB) in human hearing loss has been lacking. Here, we present multiple lines of genetic and experimental evidence linking a missense variant in

Indexed as

beta-tectorin (TECTB)deafnessHearing lossstriated sheet matrixtectorial membrane

Identifiers

PMID40832383
PMCPMC12363751

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.