Evidence map›Paper›PMID 40832793›Full record

ArticleJournal of sleep research2026

Cerebral and Peripheral Hemodynamics Across Wakefulness and NREM Sleep.

Vidhya V Nair, Brianna R Kish, Hideyuki Oshima, Qiuting Wen, Yunjie Tong, A J Schwichtenberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of sleep research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vidhya V NairWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0002-9454-8645
Brianna R KishWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Hideyuki OshimaWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Qiuting WenWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Yunjie TongWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
A J SchwichtenbergDepartment of Human Development and Family Science, College of Health and Human Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0002-8920-6798

Funding

Image based modeling of biomechanical factors for risk assessment of developing periventricular white matter hyperintensitiesR21AG068962 · NIA · PURDUE UNIVERSITY · PI TONG, YUNJIE · 2021 to 2021
$423k
NIH HHS R21AG068962NIH HHS R21AG077461-01A1
6 · The paper itself

Abstract

Wake/sleep-related changes in cerebral hemodynamic oscillations are well established, but similar changes in peripheral hemodynamics remain largely understudied. Moreover, how the relationship between cerebral and peripheral hemodynamics varies across sleep-wake states is not well understood, despite evidence that these oscillations in the low-frequency range are strongly coupled during wakefulness. In this study, we investigated the temporal and spectral characteristics of cerebral and peripheral hemodynamics, as well as their low-frequency coupling, across sleep and wake states. To this end, we simultaneously measured cerebral hemodynamics using functional magnetic resonance imaging (fMRI) of the brain and peripheral hemodynamics using near-infrared spectroscopy (NIRS) of the fingertips in 10 healthy participants (6 females; age 19-24 years, mean ± SD: 20.90 ± 1.59 years) during wakefulness and non-rapid eye movement (NREM) sleep. Our results show that during sleep, cerebral hemodynamics differ markedly from peripheral hemodynamics in both oscillation amplitude and spectral power. Furthermore, low-frequency coupling between cerebral and peripheral hemodynamics becomes desynchronized during NREM3 sleep. These findings support the notion that NREM3 sleep plays a key role in the optimal restoration of cerebral vasomotion.

Indexed as

BrainCerebrovascular CirculationHemodynamicsSleep, Slow-WaveWakefulnessAdultFemaleHumansMagnetic Resonance ImagingMaleSpectroscopy, Near-InfraredYoung Adultcerebral hemodynamicslow‐frequency oscillationsnon‐rapid eye movement sleepperipheral hemodynamics

Identifiers

PMID40832793
PMCPMC13003264

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.