ArticleJournal of Crohn's & colitis2026
Micronutrients are associated with endoscopic postoperative recurrence in Crohn's disease: a multicenter prospective cohort study in North America.
Article in Journal of Crohn's & colitis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Postoperative Recurrence in Crohn's Disease: Pathophysiology, Risk Stratification, and Management Strategies.Journal of clinical medicine · 2025Review
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Authors and funding
20 authors.
Funding
Abstract
BACKGROUND AND
aimsDiet may influence the disease course in inflammatory bowel disease, but its role in postoperative outcomes for Crohn's disease (CD) remains unclear. This study aimed to assess the association of macro- and micronutrient intake with endoscopic postoperative recurrence (ePOR) in a prospective multicenter cohort.
methodsPatients with CD following ileocolic resection were prospectively recruited from six North American centers. Primary study outcome was ePOR (modified Rutgeerts' score ≥i2a) during follow-up. Nutritional intake was assessed through 2-day food diaries verified by dietitian-delivered interview. Associations between nutrient intake and ePOR were evaluated. Random forest models with 10-fold cross-validation assessed the predictive value of nutrients and clinical factors for ePOR.
resultsA total of 520 food diaries from 103 patients were analyzed; 37 patients (36%) experienced ePOR. Univariate analysis identified 8 nutrients associated with ePOR including lower intake of isoflavones (genistein, daidzein, glycitein; P < .01), inositol (P < .01), pinitol (P = .02), provitamin-A carotenoid (P < .01), xylitol (P = .03) and parinaric Acid (P = .03). Sensitivity analysis confirmed the association of lower intake of all isoflavones (P < .01) and pinitol (P = .04) with ePOR at first postoperative colonoscopy. Random forest models showed poor discrimination for clinical factors alone (area under the curve [AUC] 0.59) but an acceptable discrimination for nutrients alone (AUC 0.67), which improved when combining nutrients and clinical factors (AUC 0.71).
conclusionLower intake of specific micronutrients is associated with ePOR in CD patients. A machine-learning model combining nutrient intake and clinical factors enhanced the prediction of ePOR. These findings highlight the importance of postoperative nutritional assessment and suggest dietary interventions may help prevent postoperative recurrence in CD.
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