ArticleCerebral cortex (New York, N.Y. : 1991)2025
Motor cortical excitability and inhibition are differentially modulated by aerobic exercise intensity.
Article in Cerebral cortex (New York, N.Y. : 1991), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Integrated virtual reality and musical biofeedback for intensity-guided training on stationary cycling: A comparative feasibility study.PLOS digital health · 2026Article
- Eccentric Cycling Improves Motor Learning More Than Concentric Cycling.Scandinavian journal of medicine & science in sports · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
Acute aerobic exercise (AEX) enhances motor learning and promotes neuroplasticity. Although previous studies examined the impact of AEX on primary motor cortex (M1) excitability, the dose-response relationship across a broad intensity spectrum with consistent exercise parameters remains to be fully elucidated. This study investigated the impact of AEX intensity on distinct M1 circuits using transcranial magnetic stimulation (TMS). Thirty right-handed adults underwent four experimental sessions: 20-min rest (control), light (LIIT: 35% heart rate reserve [HRR]), moderate (MIIT; 55% HRR), and high-intensity interval training (HIIT; 80% HRR) AEX. The interval cycling sessions alternated between 3 min at the target intensity and 2 min of active recovery (25% HRR). We performed TMS measures before (Pre), immediately post (Post0), and 20-min post (Post20) AEX/rest to assess corticospinal excitability and short-interval intracortical inhibition (SICI). We found that: (i) HIIT and MIIT increased corticospinal excitability, with HIIT eliciting a sustained increase, and (ii) all AEX intensities (LIIT, MIIT, HIIT) decreased SICI, with the greatest sustained reduction following MIIT. Altogether, our results demonstrate the impact of HIIT and MIIT to enhance corticospinal excitability and reduce SICI in M1. This study provides evidence for a dose-response effect of AEX intensity on the modulation of distinct M1 circuits.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.