New Approach to Assembling Nucleic Acid Dendrons on a Solid Phase.

Gerald J Chik, Afaf H El-Sagheer, Tom Brown

Abstract read

In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gerald J ChikDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom.ORCID 0009-0000-5217-0982

Afaf H El-SagheerDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom.

Tom BrownDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom.ORCID 0000-0002-6538-3036

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the methodology to synthesize nucleic acid dendrons on a solid support via Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC). Current methods require excess coupling reagents and result in low yields. Our alternative strategy is based on standard solid-phase synthesis followed by 5'-end coupling of a multifunction linker to efficiently afford dendrons. This approach enables the synthesis of DNA/RNA dendrons whose properties are compatible with therapeutic applications.

Indexed as

DendrimersDNANucleic AcidsRNAAlkynesAzidesCatalysisCopperCycloaddition ReactionMolecular StructureSolid-Phase Synthesis TechniquesAlkynesAzidesCopperDendrimersDNANucleic AcidsRNA

Identifiers

PMID40833369

DOI10.1021/acs.orglett.5c02877

PMCPMC12400419

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.